Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest Jonathan Elmer, Cesar.

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Presentation transcript:

Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest Jonathan Elmer, Cesar Torres, Tom P. Aufderheide, Michael A. Austin, Clifton W. Callaway, Eyal Golan, Heather Herren, Jamie Jasti, Peter J. Kudenchuk, Damon C. Scales, Dion Stub, Derek K. Richardson, Dana M. Zive Resuscitation Volume 102, Pages 127-135 (May 2016) DOI: 10.1016/j.resuscitation.2016.01.016 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Daily totals of subjects who died after out-of-hospital cardiac arrest, stratified by cause of death. Dashed line indicates the 72-h threshold before which withdrawal of life-sustaining therapy for anticipated neurological prognosis was considered to be “early”. Resuscitation 2016 102, 127-135DOI: (10.1016/j.resuscitation.2016.01.016) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 (a) The proportion of cases exposed to WLST-N versus rates of functionally favorable survival within each hospital. Exposure to WLST-N was negatively associated with functionally favorable survival (coefficient −0.23; P=0.01) (b) The proportion of cases exposed to WLST-N<72 versus rates of functionally favorable survival within each hospital. Exposure to WLST-N<72 was negatively associated with survival (coefficient −0.32; P<0.01). Resuscitation 2016 102, 127-135DOI: (10.1016/j.resuscitation.2016.01.016) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 The association of between each unexposed subject's propensity for exposure to WLST-N<72 based on baseline clinical characteristics and in-hospital mortality. The 95% confidence band of the spline curve at the highest propensity scores does not include a 1.0 probability of in-hospital mortality, indicating excess mortality associated with exposure after adjustment for baseline clinical characteristics. Resuscitation 2016 102, 127-135DOI: (10.1016/j.resuscitation.2016.01.016) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions