Volume 4, Issue 2, Pages (February 2005)

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Volume 4, Issue 2, Pages 100-110 (February 2005) Essential tremor  Dr Elan D Louis, MD MS  The Lancet Neurology  Volume 4, Issue 2, Pages 100-110 (February 2005) DOI: 10.1016/S1474-4422(05)00991-9 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 The chemical structure of harmane The Lancet Neurology 2005 4, 100-110DOI: (10.1016/S1474-4422(05)00991-9) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 The attempt of a patient with ET to draw an Archimedes spiral The Lancet Neurology 2005 4, 100-110DOI: (10.1016/S1474-4422(05)00991-9) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 3 Tremulous handwriting A patient with ET has written the words “high cholesterol”. The Lancet Neurology 2005 4, 100-110DOI: (10.1016/S1474-4422(05)00991-9) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 4 Magnetic resonance spectroscopic imaging voxels are overlaying an axial-oblique T1-weighted magnetic resonance image The voxels denote the cerebellar cortex bilaterally, a region of the brain in which metabolic changes occur. The Lancet Neurology 2005 4, 100-110DOI: (10.1016/S1474-4422(05)00991-9) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 5 Haematoxylin-eosin staining (magnification ↔100) of the locus coeruleus of a patient with ET Multiple Lewy bodies are visualised, with as many as four per neuron. The Lancet Neurology 2005 4, 100-110DOI: (10.1016/S1474-4422(05)00991-9) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 6 A fusiform axonal swelling (torpedo) is seen on a modified Bielschowsky silver stain of a cerebellar Purkinje cell Reprinted courtesy of J P G Vonsattel. The Lancet Neurology 2005 4, 100-110DOI: (10.1016/S1474-4422(05)00991-9) Copyright © 2005 Elsevier Ltd Terms and Conditions