Leksell Gamma Knife® Treatment Statistics Report 1968-2016

Leksell Gamma Knife® OVER 1 040 000 PATIENTS TREATED THROUGH 2016, WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

INDICATIONS TREATED ANNUALLY THROUGH 2016, WORLDWIDE Leksell Gamma Knife® INDICATIONS TREATED ANNUALLY THROUGH 2016, WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® CHANGE IN AVERAGE VOLUME PER CENTER, WORLDWIDE 39% increase in average treatments per center between 2000 and 2016 *2006 1st Leksell Gamma Knife Perfexion unit installed **2015 1st Leksell Gamma Knife Icon unit installed

Leksell Gamma Knife® AVERAGE NUMBER OF TREATMENTS PER REGION & CENTER Average number of treatments per center worldwide: 309 204 centers reported their data *Perfexion and Icon Centers

Leksell Gamma Knife® DISTRIBUTION OF TREATMENTS BY REGION 2016 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® GLOBAL CASE MIX BY YEAR The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® CASE MIX FOR 1968 - 2016 BY REGION The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

Leksell Gamma Knife® CASE MIX FOR 2016 BY REGION 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® TREATMENTS BY INDICATION 1968 – 2016, WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

Leksell Gamma Knife® TREATMENT COMPARISON BY INDICATION CATEGORY The percentage of centers submitting their numbers has varied between 80-95% from 2011 to 2016

Leksell Gamma Knife® INDICATIONS TREATED 1968 – 2016, WORLDWIDE *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

Leksell Gamma Knife® TREATMENTS BY INDICATION 2016, WORLDWIDE 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

INDICATIONS TREATED 2016, WORLDWIDE Leksell Gamma Knife® INDICATIONS TREATED 2016, WORLDWIDE 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® CASE MIX BY COUNTRY 2016, 9 LARGEST MARKETS CHINA TAIWAN SOUTH KOREA 2%

Leksell Gamma Knife® CASE MIX BY COUNTRY 2016, 9 LARGEST MARKETS JAPAN INDIA UNITED STATES

Leksell Gamma Knife® CASE MIX BY COUNTRY 2016, 9 LARGEST MARKETS TURKEY ITALY UNITED KINGDOM

Leksell Gamma Knife® MULTI-SESSION 2016 INDICATIONS TREATED DISTRIBUTION OF SESSIONS 105 centers reported multi- session treatment data

Leksell Gamma Knife® INDICATIONS TREATED (MULTI-SESSION) 2016 105 centers reported multi- session treatment data

Treatments with LEKSELL GAMMA KNIFE® Indication Specific Statistics 1968 - 2016

BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® BENIGN TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

BENIGN TUMORS TREATED ANNUALLY, WORLDWIDE Leksell Gamma Knife® BENIGN TUMORS TREATED ANNUALLY, WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

BENIGN TUMORS, PATIENTS TREATED WORLDWIDE CUMULATIVE Leksell Gamma Knife® BENIGN TUMORS, PATIENTS TREATED WORLDWIDE CUMULATIVE *Meningioma Grade I & II treatments reported as Meningioma prior to 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

BENIGN TUMORS, PATIENTS TREATED WORLDWIDE 2016 Leksell Gamma Knife® BENIGN TUMORS, PATIENTS TREATED WORLDWIDE 2016 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

MENINGIOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® MENINGIOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

VESTIBULAR SCHWANNOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® VESTIBULAR SCHWANNOMA, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

PITUITARY ADENOMAS, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® PITUITARY ADENOMAS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® FUNCTIONAL DISORDERS TREATED ANNUALLY, WORLDWIDE *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 ** Epilepsy treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

FUNCTIONAL DISORDERS, PATIENTS TREATED 2016 WORLDWIDE Leksell Gamma Knife® FUNCTIONAL DISORDERS, PATIENTS TREATED 2016 WORLDWIDE 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

TRIGEMINAL NEURALGIA, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® TRIGEMINAL NEURALGIA, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® FUNCTIONAL DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE EXCLUDING TRIGEMINAL NEURALGIA The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® FUNCTIONAL DISORDERS TREATED ANNUALLY, WORLDWIDE EXCLUDING TRIGEMINAL NEURALGIA *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

MALIGNANT TUMORS TREATED ANNUALLY, WORLDWIDE Leksell Gamma Knife® MALIGNANT TUMORS TREATED ANNUALLY, WORLDWIDE *Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 **Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® MALIGNANT TUMORS, CUMULATIVE PATIENTS TREATED WORLDWIDE *Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 **Malignant Glial Tumor (Grade III & IV) treatments broken down by indication after 2014 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

MALIGNANT TUMORS, PATIENTS TREATED 2016 WORLDWIDE Leksell Gamma Knife® MALIGNANT TUMORS, PATIENTS TREATED 2016 WORLDWIDE 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® METASTATIC TUMOR, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

OCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE Leksell Gamma Knife® OCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® OCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

OCULAR DISORDERS, PATIENTS TREATED 2016 WORLDWIDE Leksell Gamma Knife® OCULAR DISORDERS, PATIENTS TREATED 2016 WORLDWIDE 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® VASCULAR DISORDERS TREATED ANNUALLY, WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® VASCULAR DISORDERS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

VASCULAR DISORDERS, PATIENTS TREATED 2016 WORLDWIDE Leksell Gamma Knife® VASCULAR DISORDERS, PATIENTS TREATED 2016 WORLDWIDE 94% of all Leksell Gamma Knife centers submitted their 2016 treatment data

ARTERIOVENOUS MALFORMATIONS, CUMULATIVE PATIENTS TREATED WORLDWIDE Leksell Gamma Knife® ARTERIOVENOUS MALFORMATIONS, CUMULATIVE PATIENTS TREATED WORLDWIDE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Treatments with LEKSELL GAMMA KNIFE® Asia 1990 - 2016

Leksell Gamma Knife® OVER 520 000 PATIENTS TREATED THROUGH 2016, ASIA The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016

Leksell Gamma Knife® INDICATIONS TREATED ANNUALLY, ASIA The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016

Leksell Gamma Knife® CASE MIX 1990 – 2016, ASIA The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016

Leksell Gamma Knife® INDICATIONS TREATED 1990 – 2016, ASIA *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016

Leksell Gamma Knife® CASE MIX 2016, ASIA 99% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® INDICATIONS TREATED 2016, ASIA 99% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 185 000 PATIENTS TREATED THROUGH 2016, CHINA The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016

Leksell Gamma Knife® CASE MIX, CHINA 1993 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 12 000 PATIENTS TREATED THROUGH 2016, INDIA The percentage of centers submitting their numbers each year has varied between 68-100% from 1997 to 2016

Leksell Gamma Knife® CASE MIX, INDIA 1997 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 237 000 PATIENTS TREATED THROUGH 2016, JAPAN The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016

Leksell Gamma Knife® CASE MIX JAPAN 1990 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 53 000 PATIENTS TREATED THROUGH 2016, SOUTH KOREA The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016

Leksell Gamma Knife® CASE MIX SOUTH KOREA 1991 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1990 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 16 000 PATIENTS TREATED THROUGH 2016, TAIWAN The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016

Leksell Gamma Knife® CASE MIX TAIWAN 1993 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016 *86% of all Gamma Knife centers submitted their 2016 treatment data

Treatments with LEKSELL GAMMA KNIFE® North America 1987 - 2016

Leksell Gamma Knife® OVER 260 000 PATIENTS TREATED THROUGH 2016, NORTH AMERICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1987 to 2016 1991 reflects cumulative numbers since 1987

Leksell Gamma Knife® INDICATIONS TREATED ANNUALLY, NORTH AMERICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1987 to 2016 1991 reflects cumulative numbers since 1987

Leksell Gamma Knife® CASE MIX 1987 – 2016, NORTH AMERICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1987 to 2016

Leksell Gamma Knife® INDICATIONS TREATED 1987 – 2016, NORTH AMERICA *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1987 to 2016

Leksell Gamma Knife® CASE MIX 2016, NORTH AMERICA 86% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® INDICATIONS TREATED 2016, NORTH AMERICA 86% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 250 000 PATIENTS TREATED THROUGH 2016, UNITED STATES The percentage of centers submitting their numbers each year has varied between 68-100% from 1987 to 2016 1991 reflects cumulative numbers since 1987

Leksell Gamma Knife® CASE MIX UNITED STATES 1987 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016 *86% of all Gamma Knife centers submitted their 2016 treatment data

Treatments with LEKSELL GAMMA KNIFE® Latin America 1985 - 2016

Leksell Gamma Knife® OVER 7 200 PATIENTS TREATED THROUGH 2016, LATIN AMERICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1985 to 2016 1991 reflects cumulative numbers since 1985

Leksell Gamma Knife® INDICATIONS TREATED ANNUALLY, LATIN AMERICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1985 to 2016 1991 reflects cumulative numbers since 1985

Leksell Gamma Knife® CASE MIX 1985 – 2016, LATIN AMERICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1985 to 2016

Leksell Gamma Knife® INDICATIONS TREATED 1985 – 2016, LATIN AMERICA *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1985 to 2016

Leksell Gamma Knife® CASE MIX 2016, LATIN AMERICA 60% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® INDICATIONS TREATED 2016, LATIN AMERICA 60% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Treatments with LEKSELL GAMMA KNIFE® Europe 1968 - 2016

Leksell Gamma Knife® OVER 225 000 PATIENTS TREATED THROUGH 2016, EUROPE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® INDICATIONS TREATED ANNUALLY, EUROPE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016 1991 reflects cumulative numbers since 1968

Leksell Gamma Knife® CASE MIX 1968 – 2016, EUROPE The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

Leksell Gamma Knife® CUMULATIVE INDICATIONS TREATED 1968 – 2016, EUROPE *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1968 to 2016

Leksell Gamma Knife® CASE MIX 2016, EUROPE 100% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® INDICATIONS TREATED 2016, EUROPE 100% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 29 000 PATIENTS TREATED THROUGH 2016, ITALY The percentage of centers submitting their numbers each year has varied between 68-100% from 1991 to 2016

Leksell Gamma Knife® CASE MIX ITALY 1991 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1993 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 28 000 PATIENTS TREATED THROUGH 2016, TURKEY The percentage of centers submitting their numbers each year has varied between 68-100% from 1997 to 2016

Leksell Gamma Knife® CASE MIX TURKEY 1997 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1997 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® OVER 26 000 PATIENTS TREATED THROUGH 2016, UNITED KINGOM The percentage of centers submitting their numbers each year has varied between 68-100% from 1991 to 2016

Leksell Gamma Knife® CASE MIX UNITED KINGDOM 1991 – 2016 2016* The percentage of centers submitting their numbers each year has varied between 68-100% from 1997 to 2016 *100% of all Gamma Knife centers submitted their 2016 treatment data

Treatments with LEKSELL GAMMA KNIFE® Middle East & Africa 1996 - 2016

Leksell Gamma Knife® OVER 22 000 PATIENTS TREATED THROUGH 2016, MIDDLE EAST & AFRICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1996 to 2016

Leksell Gamma Knife® INDICATIONS TREATED ANNUALLY, MIDDLE EAST & AFRICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1996 to 2016

Leksell Gamma Knife® CASE MIX 1996 – 2016, MIDDLE EAST & AFRICA The percentage of centers submitting their numbers each year has varied between 68-100% from 1996 to 2016

Leksell Gamma Knife® CUMULATIVE INDICATIONS TREATED 1996 – 2016, MIDDLE EAST & AFRICA * *Essential Tremor treatments reported as Other Functional Disorders prior to 2012 **Meningioma Grade I & II treatments reported as Meningioma prior to 2015 ***Glioblastoma reported as Malignant Glial Tumor (Grade III & IV) prior to 2015 ****Malignant Glial Tumor (Grade III & IV) treatments broken down by indication from 2015 The percentage of centers submitting their numbers each year has varied between 68-100% from 1996 to 2016

Leksell Gamma Knife® CASE MIX 2016, MIDDLE EAST & AFRICA 88% of all Leksell Gamma Knife centers submitted their 2016 treatment data

Leksell Gamma Knife® INDICATIONS TREATED 2016, MIDDLE EAST & AFRICA * 88% of all Leksell Gamma Knife centers submitted their 2016 treatment data