Volume 62, Issue 6, Pages (June 2015)

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Volume 62, Issue 6, Pages 1391-1397 (June 2015) Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure Annika Mutanen, Jouko Lohi, Päivi Heikkilä, Hannu Jalanko, Mikko P. Pakarinen Journal of Hepatology Volume 62, Issue 6, Pages 1391-1397 (June 2015) DOI: 10.1016/j.jhep.2015.01.004 Copyright © 2015 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Serum FGF19 concentrations in patients without ileum (n=26), patients with partly (n23) or entirely (n=3) preserved ileum and healthy controls (n41). The lines, boxes and whiskers display medians, interquartile ranges and 95th percentiles, respectively. Kruskal-Wallis test with Bonferroni correction was used for multiple comparisons; p<0.001 for group effect. The p values present pairwise comparison with Mann Whitney U test. Journal of Hepatology 2015 62, 1391-1397DOI: (10.1016/j.jhep.2015.01.004) Copyright © 2015 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Serum FGF19 concentrations in patients with fibrosis (n=24), patients without fibrosis (n15), patients with portal inflammation (n=7), patients without portal inflammation (n32) and controls (n=41). The lines, boxes and whiskers display medians, interquartile ranges and 95th percentiles, respectively. Kruskal-Wallis test with Bonferroni correction was used for multiple comparisons; p<0.001 for fibrosis group effect; p<0.001 for portal inflammation group effect. The p values present pairwise comparison with Mann Whitney U test. Journal of Hepatology 2015 62, 1391-1397DOI: (10.1016/j.jhep.2015.01.004) Copyright © 2015 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Correlation between serum FGF19 concentration and METAVIR fibrosis stage (n=39). Spearman rank correlation test. Journal of Hepatology 2015 62, 1391-1397DOI: (10.1016/j.jhep.2015.01.004) Copyright © 2015 European Association for the Study of the Liver Terms and Conditions

Fig. 4 Serum interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α were increased in intestinal failure patients (n52) compared to healthy controls (n=41). In the box plot graphs the lines, boxes and whiskers display medians, interquartile ranges and 95th percentiles, respectively. P values in figures show Mann Whitney U test comparison between groups. Serum level of TNF-α and IL-6 was below the lower limit of quantification for the ELISA in 33/41 and 10/41 of controls. Journal of Hepatology 2015 62, 1391-1397DOI: (10.1016/j.jhep.2015.01.004) Copyright © 2015 European Association for the Study of the Liver Terms and Conditions