Bone structure.

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Presentation transcript:

Bone structure

Osteon

Stem cells

Osteoclast progenitors

Osteoclast precursors

Osteoclasts

Osteoblasts

Osteocytes

Bone structure (1)

Bone structure (2) New bone

Trabecular bone (1) Trabecular bone with resorption areas Normal microcracks Osteoporotic trabecular bone

Trabecular bone (2)

Bone remodeling cycle (1) Endosteal sinus Monocyte Pre-osteoclast Pre-osteoblast Osteoclast Osteoblast Bone-lining cell Osteocyte Macrophage Osteoid New bone Old bone

Bone remodeling cycle (2) Endosteal sinus Monocyte Pre-osteoclast Pre-osteoblast Osteoclast Macrophage Osteoblast Bone-lining cell Osteocyte Osteoid New bone Old bone

Bone remodeling cycle (3) Pre-osteoblasts Monocytes Osteoblasts Osteoclasts Osteocytes

Bone dimensions 100% 700% 400% Bone size (length and diameter) influences bone strength

Bone properties Bone mass Micro-architecture Connectivity Intrasic properties

Hydroxyapatite (1)

Hydroxyapatite (2)

Osteoporosis

Bone biopsies Osteoporotic bone Newly formed bone

Osteons Osteons Osteons with microcracks