The Trisynaptic Neuronal Network Of The Hippocampus.

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Presentation transcript:

The Trisynaptic Neuronal Network Of The Hippocampus. Created By: Alex Szendrei

The Hippocampus Part of the limbic system Memory and spatial navigation Located in the medial temporal lobe, underneath the cortical surface Two halves: left and right sides of the brain Resembles a seahorse, "hippo- kampos"

Parts Of Hippocampus Dentate gyrus (DG) Hippocampus proper: CA1–3 (cornu ammonis) Subicular complex: Subiculum (sb) Presubiculum (prs) Parasubiculum (pas) Entorhinal cortex (EC): Medial (MEC) Lateral (LEC)

Trisynaptic Circuit In transverse plane, three interconnected afferent pathways Three major cell groups: granule cells, CA3 pyramidal neurons, and CA1 pyramidal cells. Trisynaptic pathway Entorhinal cortex -> the dentate gyrus Dentate gyrus -> CA3 via mossy cell fibers. Ca3 -> ca1 via schaffer collaterals Ca1 -> sbiculum, carried out through the fornix. Collectively the dentate gyrus, ca1 and ca3 of the hippocampus compose the trisynaptic loop.

Thank you for your attention. Sources: Http://www.News-medical.Net/health/hippocampus-what-is-the-hippocampus.Aspx Http://neuralnetoff.Umn.Edu/mediawiki/index.Php/hippocampal_anatomy Http://www.Nature.Com/nrn/journal/v9/n1/fig_tab/nrn2303_f1.Html Https://en.Wikipedia.Org/wiki/trisynaptic_circuit Http://www.Scholarpedia.Org/article/entorhinal_cortex Https://www.Ncbi.Nlm.Nih.Gov/pmc/articles/PMC2492885/ Http://neuroscience.Uth.Tmc.Edu/s4/chapter05.Html Https://www.Cs.Cmu.Edu/afs/cs/academic/class/15883-f13/slides/hc-anatomy.Pdf