Volume 386, Issue 9990, Pages (July 2015)

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Volume 386, Issue 9990, Pages 258-265 (July 2015) Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis Prof Jasvinder A Singh, MBBS, MPH, Chris Cameron, MSc, Shahrzad Noorbaloochi, BA, Tyler Cullis, MA, Matthew Tucker, BSc, Robin Christensen, PhD, Elizabeth Tanjong Ghogomu, BSc, Doug Coyle, PhD, Tammy Clifford, PhD, Prof Peter Tugwell, MD, Prof George A Wells, PhD The Lancet Volume 386, Issue 9990, Pages 258-265 (July 2015) DOI: 10.1016/S0140-6736(14)61704-9 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Study selection The Lancet 2015 386, 258-265DOI: (10.1016/S0140-6736(14)61704-9) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 2 Evidence networks for serious infection in populations The width of the lines is proportional to the number of randomised trials being compared in each pair of treatments. The size of each treatment node is proportional to the number of participants (sample size). Doses are defined in the appendix. DMARD=disease-modifying antirheumatic drugs. SD=standard dose. HD=high dose. LD=low dose. The Lancet 2015 386, 258-265DOI: (10.1016/S0140-6736(14)61704-9) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 3 Traditional meta-analysis and network meta-analysis Risk of serious infection among specified populations of patients compared with patients receiving traditional DMARD monotherapy. Data for the traditional meta-analysis are OR (95% CI) and data for the network meta-analysis are OR (95% Crl). OR=odds ratio. CrI=credible interval. DMARD=disease-modifying antirheumatic drugs. The Lancet 2015 386, 258-265DOI: (10.1016/S0140-6736(14)61704-9) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 4 Cumulative meta-analysis Risk of serious infection among specified populations of patients compared with patients receiving traditional DMARD monotherapy. OR=odds ratio. DMARDs=disease-modifying antirheumatic drugs. The Lancet 2015 386, 258-265DOI: (10.1016/S0140-6736(14)61704-9) Copyright © 2015 Elsevier Ltd Terms and Conditions