WFH GAP Program Alain Weill, WFH President March 5, 2017

GLOBAL ALLIANCE FOR PROGRESS (GAP) Program Flagship WFH healthcare development project Launched in 2003 Foster partnership between government, healthcare providers and patients Develop sustainable national care programs Multi-sponsored program 2

GAP: 10 YEAR STRATEGIC GOALS (2013-2022) Second Decade of GAP Identifying an additional 50,000 people with inherited bleeding disorders by 2022, with 50% of them living in the world’s poorest regions Results to date 30,296 have been identified globally Including 6,852 from the poorest countries 3

GAP Second Decade: Components Tier 1 Continue successful strategy of GAP Tier 2 Advance achievements post gap Tier 3 Assist countries with mid-level treatment As we continue to serve new countries under the GAP program, we will also make efforts to advance further the gains in those countries that have already completed GAP and also start work in countries with mid level treatment so as to try to get them to the next level of care. In this phase we will also enhance data collection process as well as extend the focus of diagnosis and treatment to patients with inhibitors, VWD, the rarer coagulation factor deficiencies, platelet disorders and with a special attention also to women with these disorders. 4

GAP Second Decade: Components Full-GAP Program: Continuation of current GAP working on all 6 pillars of WFH Development Steps Model Post-GAP Program: Post-GAP countries which would benefit from additional support in advancing a National Country Program, building up on GAP Phase 1 achievements or improving sustainability of Phase 1 Mid-Level GAP Program: Intermediate level countries which need help in moving forward to the next level of care 5

WFH DEVELOPMENT MODEL A step-by-step process to reach sustainable care across six distinct but interrelated pillars Improve medical expertise and increase accurate laboratory diagnosis through training Build a strong national patient organization through capacity Achieve government support through advocacy Increase access to safe treatment products Track national demographic data Improve care delivery The WFH works globally to close the gap in care between those who receive proper treatment and those who do not A step-by-step process to bring about sustainable care across six distinct but interrelated pillars INCREASING ACCURATE LABORATORY DIAGNOSIS IMPROVING MEDICAL EXPERTISE AND CARE DELIVERY THROUGH TRAINING BUILDING A STRONG NATIONAL PATIENT ORGANIZATION THROUGH CAPACITY ACHIEVING GOVERNMENT SUPPORT THROUGH ADVOCACY INCREASING ACCESS TO SAFE TREATMENT PRODUCTS TRACKING NATIONAL DEMOGRAPHIC DATA 6

GAP PARTICIPATING COUNTRIES: 2003-2016 Russia Belarus Serbia Georgia China Moldova Azerbaijan Jordan Armenia Tunisia Lebanon Turkey Vietnam Mexico Honduras Morocco Egypt Syria Thailand Philippines Colombia Algeria Ecuador Peru Brazil South Africa TOTAL: 26 countries / 31 programs 7

GAP Overall achievements: 2003-2016 81,212 new PWH diagnosed/registered globally (end 2015) 26 countries enrolled; 31 multi-year national bleeding disorder care development plans drawn up 19 GAP MoU signed 29,247 PWH / 4,824 VWD / 3,160 RBD diagnosed in GAP countries 16,449 new patients, family members, and (NMO) board members trained / 23,366 medical professionals trained Treatment product access: Over 4.642 billion IUs purchased 8

GAP ACHIEVEMENTS: January - DECEMBER 2016 Overall Results 12 active countries / closing of GAP South Africa and GAP Moldova (end 2015) 4 new GAP countries in 2016: Vietnam (T1), China (T2), Morocco (T2), and Turkey (T3) 2 GAP MoUs signed (Jordan, Vietnam) and continued discussions and negotiations on other MoUs (Honduras, Serbia) Continued collaboration following signed MoUs (Algeria, Colombia, Egypt and Morocco) 462 new patients with hemophilia, 157 with VWD, 134 with rare clotting factor deficiencies diagnosed / registered in GAP countries Over 710 million IUs increase in product supply 9

TOTAL: 13 2017 gap COUNTRY PROGRAMS Europe Serbia Turkey Americas Asia Colombia Honduras Brazil Uruguay (NEW Tier 3) Asia China Vietnam Malaysia (NEW Tier 3) Middle East Egypt Jordan Morocco Tunisia (NEW Tier 2) TOTAL: 13 10

GAP VIETNAM (TIER 1 –FULL-GAP PROGRAM) Population (2014): 93,421,835 GNI per capita (2015): 1,980 (US$) Public Health expenditure,(% of GDP) (2014): 3.8 Expected number of people with hemophilia / prevalence: 6,213 Confirmed number of people with hemophilia (2014): 2,373 Factor VIII usage (2014): 0.099 IU per capita *Population, Confirmed number of PWH & Factor VIII usage : Global Survey 2014 *GNI per capita & Public Health expenditure: World Bank

GAP MOU signing ceremony: September 21,2016

GAP planning visit – February 13-14, 2017 During February 13-14, 2017, a visit was organized in Vietnam to develop a detailed action plan for the GAP Program.

VIETNAM DEVELOPMENT PLAN: MAIN OBJECTIVES Government support for a national hemophilia care program Strengthening exiting network of 7 hemophilia treatment centres Development of medical expertise of HCPs in selected 7 HTCs Increase the supply of factor concentrates and increase factor concentrates access for patients Expand NMO and increase its lay leadership and number of active volunteers Support development and implementation a national registry

Support to Vietnam through other programs Vietnam – Ireland HOT Twinning Program, 2011-2014 Hanoi (NIHBT) – Melbourne (Alfred Hospital) HTC Twinning Program 2011-2014 Participation in the WFH Global NMO Training, international meetings, and congresses WFH Humanitarian Aid Program donations (3 M ius in 2016) Improve laboratory diagnosis standards through participation in IEQAS Training of healthcare professionals through WFH IHTC Fellowship Program Participation in the ASEAN Hemophilia Network meetings/ workshops

THANK YOU