From: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 DiabetesA Systematic Review and Meta-analysis Ann Intern Med.

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From: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 DiabetesA Systematic Review and Meta-analysis Ann Intern Med. 2016;164(11):740-751. doi:10.7326/M15-2650 Figure Legend: † Comorbid condition restrictions were end-stage renal disease, end-stage liver disease, cancer, new-onset diabetes after transplant, or a cardiovascular event within 3 mo (such as acute coronary syndrome, acute myocardial infarction, post–coronary artery bypass graft surgery, or drug-eluting stents). Date of download: 10/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 DiabetesA Systematic Review and Meta-analysis Ann Intern Med. 2016;164(11):740-751. doi:10.7326/M15-2650 Figure Legend: All differences for HbA1c are absolute percentage-point differences. BL = baseline; DPP-4 = dipeptidyl peptidase-4; GLP-1 = glucagon-like peptide-1; HbA1c = hemoglobin A1c; Met = metformin; PLE = profile likelihood estimate; SGLT-2 = sodium–glucose cotransporter 2; SU = sulfonylurea; TZD = thiazolidinedione. Date of download: 10/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 DiabetesA Systematic Review and Meta-analysis Ann Intern Med. 2016;164(11):740-751. doi:10.7326/M15-2650 Figure Legend: BL = baseline; DPP-4 = dipeptidyl peptidase-4; GLP-1 = glucagon-like peptide-1; Met = metformin; PLE = profile likelihood estimate; SGLT-2 = sodium–glucose cotransporter 2; SU = sulfonylurea; TZD = thiazolidinedione; wt = weight. Date of download: 10/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 DiabetesA Systematic Review and Meta-analysis Ann Intern Med. 2016;164(11):740-751. doi:10.7326/M15-2650 Figure Legend: Relative risk for hypoglycemia shown by ranges in absolute RDs across study groups and as pooled odds ratios. DPP-4 = dipeptidyl peptidase-4; Met = metformin; PLE = profile likelihood estimate; RD = risk difference; SGLT-2 = sodium–glucose cotransporter 2; SU = sulfonylurea; TZD = thiazolidinedione. Date of download: 10/12/2017 Copyright © American College of Physicians. All rights reserved.

From: Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 DiabetesA Systematic Review and Meta-analysis Ann Intern Med. 2016;164(11):740-751. doi:10.7326/M15-2650 Figure Legend: DPP-4 = dipeptidyl peptidase-4; GI = gastrointestinal; GLP-1 = glucagon-like peptide-1; Met = metformin; RD = risk difference; SGLT-2 = sodium–glucose cotransporter 2; SU = sulfonylurea; TZD = thiazolidinedione. Date of download: 10/12/2017 Copyright © American College of Physicians. All rights reserved.