GnRH-I AND II INDUCED EFFECTS IN HUMAN OVARIAN CELLS By In Sun, Hong Reproductive and Developmental Science program Department of Obstetrics and Gynecology The University of British Columbia

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What is the functional role and molecular mechanism of GnRH-I and II in human granulosa cells?

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GnRH-I or II exert anti-proliferative effects on human granulosa cells by interfering with the IGF-I activity

The attenuating effects of GnRH-I or II on the activity of IGF-I in granulosa cells apoptosis

GnRH-I or II interfere with IGF-I induced Akt signaling pathways

GnRH-I or II interfere with IGF-I induced Akt signaling pathways

1 2 Two possible mechanisms of GnRH-I or II induced anti-proliferative effects in human granulosa cells 1 2 GnRH-I, II GnRH-I, II IGF-I Caspase-dependent pathway Akt Apoptosis IGF-I activity

Acknowledgements: Dr. Leung’s Lab Dr. Peter CK Leung Dr. Christian Klausen Jordan Cheng Raymond Lau Kelvin So William Chang Mya Zhang