4University of Cincinnati Medical Center, Cincinnati, OH/USA.

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4University of Cincinnati Medical Center, Cincinnati, OH/USA. Roflumilast reduces circulatory IL17 levels in subjects with sarcoidosis and pulmonary fibrosis M.D. Schweitzer1, O. Salamo1, M. Mirsaeidi1, M. Campos1, M. Judson2, D.A. Culver3, E.E. Lower4, R.P. Baughman4. 1University of Miami, Miami, FL/USA. 2Albany Medical College, Albany, NY/USA. 3Cleveland Clinic Foundation, Cleveland, OH/USA. 4University of Cincinnati Medical Center, Cincinnati, OH/USA. Background Results Sarcoidosis is a well known Th1 lymphocytic disorder. Interleukin 17 (IL17) is a T-cell pro-inflammatory cytokine implicated in the pathogenesis of granuloma formation in sarcoidosis. Roflumilast is a phosphodiesterase 4 (PDE-4) inhibitor, used to decrease exacerbations in COPD. Its in vivo effect on inflammatory mediators in sarcoidosis has not been studied. IL-1a IL-1b IL-2 IL-4 Objective To evaluate the effect of roflumilast on serum cytokines in subjects with fibrotic pulmonary sarcoidosis (FPS). Methods IL-5 IL-6 IL-8 IL-10 Analysis of serum samples from a trial to evaluate the effect of roflumilast on cytokines in FPS subjects. Roflumilast = 6 subjects. Placebo = 5 subjects. Blood samples were collected at baseline (month 0), 6 months and 12 months. Cytokine analysis was performed with Multiplex 18 Cytokines test (Quansys Biosciences). Conclusions IL-12 IL-13 IL-15 IL-17 Roflumilast use was associated with a significant decrease in IL17 levels after 6 months therapy. Given the central role of IL17 in the preservation of granuloma in sarcoidosis, roflumilast may have therapeutic potential in this condition. We acknowledge funding from Astra-Zeneca.