SWAG SSG Urology Meeting Clinical Research Network West of England SWAG SSG Urology Meeting Thursday 13th October 2016 Maxine Taylor Senior Research Delivery Manager – Cancer, Surgery, Genetics, Haematology. Workforce Development Lead

Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltsire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network

NIHR CRN – what does it do? Infrastructure that allows high-quality clinical research to take place in the NHS Help researchers to set up clinical studies quickly and effectively Support the life-sciences industry to deliver their research programmes in the NHS Provide health professionals with research training Work with patients to ensure their needs are at the very centre of all research activity.

NIHR CRN High Level Objectives Increase number of participants into NIHR CRN portfolio studies 650,000 in England 21,905 in West of England Increase the number of studies that deliver to time and target Target 80% Increase number of commercial studies delivered through network 650 new studies this year 75% of all commercial studies Reduce NHS study set up times Reduce time taken to recruit first participant

Local Clinical Research Networks Translation of national objectives for clinical research Oversight of research activity within the geography of CRN - West of England in terms of: Portfolio Balance, new studies, feasibility, set up, industry trials Performance Support, network wide solutions, targets People Patient involvement, staff skill mix & flexibility, training, resources

30 Clinical Specialties Ageing Anaesthetics & pain Cancer Cardiovascular Children Critical Care Dementia & Neurodegenerative Dermatology Diabetes ENT Gastroenterology Genetics Haematology Health Services Hepatology Infectious Diseases Injuries & Emergencies Mental Health Metabolic & Endocrine Musculoskeletal Neurological Opthalmology Oral & Dental Primary Care Public Health Renal Reproductive Health Respiratory Stroke Surgery

Including lymphoma

Local CRN sub specialty leads NCRI Clinical Studies Groups NIHR CRN cancer leadership

National Clinical Studies Groups PPI Psychosocial & Survivorship Imaging Adv. panel Breast Cancer CSG Brain Tumours CSG Lung Cancer CSG Palliative & Supportive Care Head & Neck CSG Biomarkers Adv. panel Upper GI Cancer CSG Consumer Liaison Group Sarcoma CSG PPI Colorectal Cancer CSG Melanoma CSG Kidney Cancer CSG Primary Care Lymphoma CSG Bladder Cancer CSG Screening, Prevention & Early Diagnosis Haematol. CSG Testis Cancer CSG Prostate Cancer CSG Gynae Cancer CSG Children’s Cancer & Leukaemia Teenage & Young Adult CTRad (Radiotherapy)

Cancer sub specialty lead role Communicate and collaborate with clinical colleagues across the network re the portfolio of studies in their sub specialty Action plan in place to increase access to research Mapping portfolio across the network Shared portfolio of studies Improve referral pathways for research Encourage more referral for research Consider economies of scale for rare disease studies Network wide planning for EOIs Support and encourage teams to meet study targets

NIHR CRN Objectives for cancer Recruit 20% of cancer incidence West of England 1,909 Recruit 7.5% of cancer incidence into interventional studies 716 Include challenging studies Cancer surgery – 4 recruits per 100,000 population Radiotherapy – 6 recruits per 100,000 population Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population Children & young people – 3 per 100,000 population Teenagers & young adults – record number of 16-15 year olds participating in research

Open studies in SWAG - Bladder Project Title Chief Investigator Project type Site parent organisation Principal Investigator BRAG rating Project site planned recruitment end date Recruited (total) Project site target participants WO29636 - MPDL3280A in muscle invasive bladder cancer Birtle Registrar, Dr Alison Commercial portfolio University Hospitals Bristol NHS Foundation Trust Bahl, Dr Amit 01/10/2017 5 RAIDER Huddart, Prof Robert Non-commercial portfolio Gloucestershire Hospitals NHS Foundation Trust Jenkins, Dr Peter 01/03/2018 12 POUT Birtle, Alison Great Western Hospitals NHS Foundation Trust Khan, Dr Omar 31/03/2019 1 3 North Bristol NHS Trust Keeley, Mr Francis 31/12/2016 6 7 30/06/2017 2 10 JAVA-P 01/08/2020 4 Hyperthermia for Intermediate risk bladder cancer (HIVEC-II) Royal United Hospitals Bath NHS Foundation Trust Phull, Mr Jaspal 30/09/2017 8 CALIBER Mostafid, Mr Hugh Davenport, Miss Kim 01/06/2018 30 BRAG Open studies Black Study not reported recruitment or study has not recruited Red % Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30 Amber % Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0 Green % Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0 Grey Unable to calculate RAG due to record missing at least one data point

Open studies in SWAG - Prostate Project Title Chief Investigator Project type Site parent organisation Principal Investigator BRAG rating Project site planned recruitment end date Recruited (total) Project site target participants VIABLE Pandha, Prof Hardev Commercial portfolio University Hospitals Bristol NHS Foundation Trust Bahl, Dr Amit 16/10/2016 12 6 UK Genetic Prostate Cancer Study Eeles, Prof Rosalind Non-commercial portfolio Gloucestershire Hospitals NHS Foundation Trust Cook, Dr Audrey 31/12/2017 117 56 Great Western Hospitals NHS Foundation Trust Cole, Dr David 31 10 North Bristol NHS Trust Persad, Mr Rajendra AR 224 200 Royal United Hospitals Bath NHS Foundation Trust Newman, Dr Hugh 131 20 51 Weston Area Health NHS Trust Hilman, Dr Serena 26 True NTH UK Post Surgical Follow Up Moore, Mrs Caroline M Koupparis, Mr Anthony 31/03/2017 50 Stampede McNicholas, Dr James Bowen, Dr Jo 31/12/2020 48 14 Khan, Dr Omar 46 5 Frim, Dr Olivera 30/09/2015 71 02/02/2018 93 42 31/12/2016 18 4

Site parent organisation Principal Investigator BRAG rating Project Title Chief Investigator Project type Site parent organisation Principal Investigator BRAG rating Project site planned recruitment end date Recruited (total) Project site target participants SAPROCAN: Saracatnib and docetaxel in met, cast-ref prostate cancer Jones, Dr Robert Non-commercial portfolio University Hospitals Bristol NHS Foundation Trust Bahl, Dr Amit 01/09/2019 13 8 RADICALS (MRC PR10) Parker, Dr Christopher Gloucestershire Hospitals NHS Foundation Trust Bowen, Dr Jo 30/06/2015 16 26 Great Western Hospitals NHS Foundation Trust Khan, Dr Omar 31/12/2016 10 2 North Bristol NHS Trust Persad, Mr Rajendra AR 40 88 Royal United Hospitals Bath NHS Foundation Trust Frim, Dr Olivera 33 24/07/2018 27 20 Weston Area Health NHS Trust Hilman, Dr Serena 03/05/2013 23 12 PROMPTS Dearnaley, Prof David 31/12/2017 31/07/2015 5 ProCAID Crabb, Dr Simon Kehagioglou , Dr Penny 29/12/2017 PATCH ABEL, Prof Paul McFarlane, Mr Jonathan 01/09/2017 6 30/06/2018

Site parent organisation Principal Investigator BRAG rating Project Title Chief Investigator Project type Site parent organisation Principal Investigator BRAG rating Project site planned recruitment end date Recruited (total) Project site target participants IMPACT Eeles, Prof Rosalind Non-commercial portfolio University Hospitals Bristol NHS Foundation Trust Donaldson, Dr Alan 31/12/2016 2 20 ENZARAD Hughes, Dr Simon Royal United Hospitals Bath NHS Foundation Trust Beresford, Dr Mark 13/07/2020 1 10 ENZAMET Chowdhury, Dr Simon Great Western Hospitals NHS Foundation Trust Khan, Dr Omar 01/04/2017 6 CANC - 4381 PREMISE Robinson, Dr Angus Commercial portfolio 30/06/2018 11 Weston Area Health NHS Trust Hilman, Dr Serena 31/10/2016 ATLAS: JNJ56021927 (ARN509) Bahl, Dr Amit 01/04/2019 ARAMIS Birtle, Alison 30/06/2020 4

Open studies in SWAG - Renal Project Title Chief Investigator Project type Primary Clinical Studies Group Site parent organisation Principal Investigator BRAG rating Project site planned recruitment end date Recruited (total) Project site target participants STAR Standard vs Modified Drug Therapy in Renal Cancer Brown, Dr Janet Non-commercial portfolio Renal Gloucestershire Hospitals NHS Foundation Trust Farrugia, Dr David 01/05/2017 10 16 Great Western Hospitals NHS Foundation Trust Khan, Dr Omar 31/05/2017 7 8 Royal United Hospitals Bath NHS Foundation Trust Beresford, Dr Mark 30/05/2017 12 5 Pazopanib in patients with renal cancer (PaZ02) Porfiri, E 30/06/2016 11 6 University Hospitals Bristol NHS Foundation Trust Bahl, Dr Amit 31/08/2016 2 A-PREDICT Larkin, Dr James 31/12/2016 No studies currently open for Testis cancer

Studies in set up - Renal CANC – 3263 ADONIS In set up at Royal United Hospitals Bath NHS Foundation Trust, PI Dr Mark Beresford.

Useful links https://www.crn.nihr.ac.uk/ National and local network information including training programmes templates, tools, contacts, videos etc https://odp.nihr.ac.uk/ http:/ Open data platform. Look at performance across whole CRN including all specialty areas /csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and ‘in set up’ cancer studies https://www.ukctg.nihr.ac.uk/ See where a study is open across the country http://public-odp.nihr.ac.uk/  Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

Contacts Research Delivery Manager – maxine.taylor@nihr.ac.uk Cancer portfolio facilitator – richard.munday@nihr.ac.uk