Low Testosterone Levels and Reduced Kidney Function in Japanese Adult Men: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study  Noriaki Kurita,

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Low Testosterone Levels and Reduced Kidney Function in Japanese Adult Men: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study  Noriaki Kurita, MD, FJSIM, PhD, Shigeo Horie, MD, PhD, Shin Yamazaki, PhD, Koji Otani, MD, PhD, Miho Sekiguchi, MD, PhD, Yoshihiro Onishi, MPH, PhD, Misa Takegami, RN, PhD, Rei Ono, MPH, PhD, Shin-ichi Konno, MD, PhD, Shin-ichi Kikuchi, MD, PhD, Shunichi Fukuhara, MD, DMSc, MACP  Journal of the American Medical Directors Association  Volume 17, Issue 4, Pages 371.e1-371.e6 (April 2016) DOI: 10.1016/j.jamda.2016.01.011 Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 1 Flow chart of study participants. Sum of number of participants with missing values for salivary testosterone (sT) and outcome variables (eGFR) exceeds 145 because 25 participants had missing values for 2 variables. Journal of the American Medical Directors Association 2016 17, 371.e1-371.e6DOI: (10.1016/j.jamda.2016.01.011) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 2 Box plots for salivary testosterone (sT) levels stratified by age categories. The white line in the boxes indicates median sT in each category. The top and bottom of the boxes indicate 75th and 25th percentiles of sT in each category, respectively. Journal of the American Medical Directors Association 2016 17, 371.e1-371.e6DOI: (10.1016/j.jamda.2016.01.011) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 3 Adjusted difference in eGFR rate in men with aged over 40 years. Linear regression model with restricted cubic spline adjusted for covariates (age, body mass index, smoking history, SBP, DBP, diabetes, dyslipidemia, cerebrovascular disease, and heart disease). The 90th percentile of salivary testosterone (sT) level (ie, median of the fifth quintile) was cited as reference. The left vertical axis shows difference in eGFR, and the solid line indicates point estimates of eGFR while dotted lines indicate CIs. Gray bars indicate frequency of the sT values. The right vertical axis shows frequency of each gray bar. CI, Confidence interval. Journal of the American Medical Directors Association 2016 17, 371.e1-371.e6DOI: (10.1016/j.jamda.2016.01.011) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions