Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men Amir Tirosh, M.D., Ph.D.,Iris Shai, R.D., Ph.D., Dorit Tekes-Manova, M.D., Eran.

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Presentation transcript:

Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men Amir Tirosh, M.D., Ph.D.,Iris Shai, R.D., Ph.D., Dorit Tekes-Manova, M.D., Eran Israeli, M.D., David Pereg, M.D., Tzippora Shochat, M.Sc., Ilan Kochba, M.D., and Assaf Rudich, M.D., Ph.D., for the Israeli Diabetes Research Group N Engl J Med 2005;353:1454-62.

Background Normal fasting plasma glucose Revised by American Diabetes Association Impaired fasting plasma glucose 100~109 mg/dl (5.55~6.05 mmol/L) Increased risk for diabetes Elevated fasting plasma glucose within normal range Risk factor?

Aim fasting plasma glucose levels identify young, healthy, normoglycemic persons increased risk for type 2 diabetes?

Methods The Melany study Inclusion and exclusion criteria Israel Defense Forces Staff Periodic Exam Inclusion and exclusion criteria 1992~2004 13163 men with fasting plasma glucose<100 mg/dl Excluded: type 1 or 2 diabetes, women,

Result

Conclusion Higher fasting plasma glucose levels within the normoglycemic range independent risk factor for type 2 diabetes among young men. BMI and triglyceride levels identify healthy men at increased risk for diabetes.