Volume 115, Issue 6, Pages 1553-1562 (June 1999) Respiratory Muscle Function and Hypoxic Ventilatory Control in Patients With Type I Diabetes Mancini Marco , MD, Filippelli Mario , MD, Seghieri Giuseppe , MD, Iandelli Iacopo , MD, Innocenti Fabio , MD, Duranti Roberto , MD, Scano Giorgio , MD, FCCP CHEST Volume 115, Issue 6, Pages 1553-1562 (June 1999) DOI: 10.1378/chest.115.6.1553 Copyright © 1999 The American College of Chest Physicians Terms and Conditions
Figure 1 Maximal Pessn and Pdisn in the eight diabetic patients. CHEST 1999 115, 1553-1562DOI: (10.1378/chest.115.6.1553) Copyright © 1999 The American College of Chest Physicians Terms and Conditions
Figure 2 Average breathing pattern of patients and control subjects. Ascendant limb is the ratio of Vt to Ti. Descendant limb is the ratio of expiratory Vt to Te. Ti + Te = Ttot; 1/Ttot × 60 = Rf. Dashed line represents control subjects; continuous line, diabetic patients. CHEST 1999 115, 1553-1562DOI: (10.1378/chest.115.6.1553) Copyright © 1999 The American College of Chest Physicians Terms and Conditions
Figure 3 Relationships of e and Pessw(%Pessn) vs Sao2 during progressive hypoxia. Individual regression lines for both patients and normal subjects are shown. CHEST 1999 115, 1553-1562DOI: (10.1378/chest.115.6.1553) Copyright © 1999 The American College of Chest Physicians Terms and Conditions
Figure 4 Plot of Pessw vs Vt during hypoxic rebreathing. Area depicts the range of the response in the normal control group. Individual regression lines for patients are shown. CHEST 1999 115, 1553-1562DOI: (10.1378/chest.115.6.1553) Copyright © 1999 The American College of Chest Physicians Terms and Conditions
Figure 5 Plot of swings in Pes vs swings in Pg during progressive hypoxia in patients. Open symbols represent values at end expiration; closed symbols, values at end inspiration. Circles indicate 95% Sao2; squares, 80%; triangles, 72%. At 95% Sao2, the increase in inspiratory Pes was associated with an increase in Pg such that the line joining the end-expiratory point to the end-inspiratory point had a positive slope representing the combined action of the diaphragm and the rib cage inspiratory muscles. During progressive hypoxic stimulation, the end-expiratory point shifted to a greater Pg, indicating expiratory muscle recruitment. CHEST 1999 115, 1553-1562DOI: (10.1378/chest.115.6.1553) Copyright © 1999 The American College of Chest Physicians Terms and Conditions
Figure 6 Plot of swings in Pes vs swings in Pg during progressive hypoxia in control subjects. Average data are shown. See Figure 5 legend for explanation of the figure and the symbols used. CHEST 1999 115, 1553-1562DOI: (10.1378/chest.115.6.1553) Copyright © 1999 The American College of Chest Physicians Terms and Conditions