You-Lin Tain, Kay L.H. Wu, Wei-Chia Lee, Steve Leu, Julie Y.H. Chan

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Maternal fructose-intake-induced renal programming in adult male offspring You-Lin Tain, Kay L.H. Wu, Wei-Chia Lee, Steve Leu, Julie Y.H. Chan Journal of Nutritional Biochemistry Volume 26, Issue 6, Pages 642-650 (June 2015) DOI: 10.1016/j.jnutbio.2014.12.017 Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 1 Effects of maternal HF or normal diet (control) on (A) systolic and (B) diastolic BPs measured in male offspring at 3, 4, 8 and 12 weeks postnatal. Data are mean±S.E.M., n=6 per group. *P<.05 vs. control in unpaired t test. Journal of Nutritional Biochemistry 2015 26, 642-650DOI: (10.1016/j.jnutbio.2014.12.017) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 2 Venn diagram depicting unique and shared (overlapping circles) sets of DEGs in offspring exposed to maternal HF intake between 1 day (black circle), 3 weeks (gray circle) and 3 months (white circle) of age. A total of 10 significantly related KEGG pathways shared by 3 different developmental windows are listed in the right panel. Total number, as well as number of up- or down-regulated genes identified during each time window, is also indicated. Journal of Nutritional Biochemistry 2015 26, 642-650DOI: (10.1016/j.jnutbio.2014.12.017) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 3 (A) Effect of HF intake on gene expression of RAS components in the kidney of rats at 3 months of age. Data shown are confirmatory analysis of genes derived from RNA-Seq by qPCR in HF vs. control (n=6 in each group). (B) Effects of HF on gene expression of arachidonic acid metabolism pathway in the kidney from offspring at 1 day, 3 weeks and 3 months postnatal. (C) Representative Western blot gels and relative abundance of renal sEH protein (62 kDa) in male offspring kidneys at 3 weeks of age. (D) Effect of maternal HF on renal level of DHET in offspring kidneys at 3 weeks of age. Data are mean±S.E.M., n=6 per group. *P<.05 vs. control in unpaired t test. Journal of Nutritional Biochemistry 2015 26, 642-650DOI: (10.1016/j.jnutbio.2014.12.017) Copyright © 2015 Elsevier Inc. Terms and Conditions