Jong Wook Kim, Hoon Ah Jang, Jae Hyun Bae, Jeong Gu Lee

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Effects of Coenzyme Q10 on Bladder Dysfunction Induced by Chronic Bladder Ischemia in a Rat Model Jong Wook Kim, Hoon Ah Jang, Jae Hyun Bae, Jeong Gu Lee The Journal of Urology Volume 189, Issue 6, Pages 2371-2376 (June 2013) DOI: 10.1016/j.juro.2012.12.101 Copyright © 2013 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 1 Representative cystometric curves show significantly shorter intercontraction interval in untreated CBI group than in other groups. Arrows indicate nonvoiding contractions. A, untreated sham operated rats. B, CoQ10 treated sham operated rats. C, untreated CBI rats. D, CoQ10 treated CBI rats. The Journal of Urology 2013 189, 2371-2376DOI: (10.1016/j.juro.2012.12.101) Copyright © 2013 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 2 Carbachol induced contraction of detrusor muscle strip from untreated, sham operated (filled circles), CoQ10 treated, sham operated (open circles), untreated CBI (filled triangles) and CoQ10 treated CBI (open triangles) rats. Contractile responses induced by carbachol in untreated CBI and CoQ10 treated CBI rats were lower than in untreated, sham operated and CoQ10 treated, sham operated rats at 10−5 to 10−4 mol/L dose. Contractile responses induced by carbachol in CoQ10 treated CBI rats were significantly higher than in untreated CBI rats at 10−5 to 10−3 mol/L dose. Data represent mean ± SD in 6 rats. g, gm. Asterisk indicates p <0.05 vs untreated CBI rats. Dagger indicates p <0.05 vs untreated sham operated rats. Double dagger indicates p <0.05 vs CoQ10 treated sham operated rats. The Journal of Urology 2013 189, 2371-2376DOI: (10.1016/j.juro.2012.12.101) Copyright © 2013 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 3 Microscopic features of bladder wall section. A, no abnormal findings in untreated sham operated rats. B, untreated CBI rats showed moderate submucosal fibrosis (arrow). C, CoQ10 treated CBI rats showed minimal submucosal fibrosis (arrows). H & E, reduced from ×100. Scale bar represents 100 μm. The Journal of Urology 2013 189, 2371-2376DOI: (10.1016/j.juro.2012.12.101) Copyright © 2013 American Urological Association Education and Research, Inc. Terms and Conditions

Figure 4 Microscopic features of common iliac artery section. A, no intimal lesion in untreated, sham operated rats. B, untreated CBI rats showed irregular intimal thickening (arrowheads) and degenerative change in tunica media (arrows). C, CoQ10 treated CBI rats showed less degenerative tunical media change (arrows). H & E, reduced from ×100. Scale bar represents 100 μm. The Journal of Urology 2013 189, 2371-2376DOI: (10.1016/j.juro.2012.12.101) Copyright © 2013 American Urological Association Education and Research, Inc. Terms and Conditions