Md Soriful Islam, Ph. D. , Olga Protic, M. Sc

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Presentation transcript:

Complex networks of multiple factors in the pathogenesis of uterine leiomyoma Md Soriful Islam, Ph.D., Olga Protic, M.Sc., Piergiorgio Stortoni, M.D., Gianluca Grechi, M.D., Pasquale Lamanna, M.D., Felice Petraglia, M.D., Mario Castellucci, M.D., Ph.D., Pasquapina Ciarmela, Ph.D. Fertility and Sterility Volume 100, Issue 1, Pages 178-193 (July 2013) DOI: 10.1016/j.fertnstert.2013.03.007 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Fundamental factors involved in the pathogenesis of uterine leiomyoma (the cells in the photographs are primary cells cultured in our laboratory). Fertility and Sterility 2013 100, 178-193DOI: (10.1016/j.fertnstert.2013.03.007) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Interaction of estrogen (A) and P (B) with growth factors, and their signaling pathways in leiomyoma growth. Fertility and Sterility 2013 100, 178-193DOI: (10.1016/j.fertnstert.2013.03.007) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Fibronectin staining in human leiomyoma tissues detected by immunohistochemistry performed in our laboratory. Fertility and Sterility 2013 100, 178-193DOI: (10.1016/j.fertnstert.2013.03.007) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Representation of hypothetical possible therapies to inhibit uterine fibroid formation and growth. Fertility and Sterility 2013 100, 178-193DOI: (10.1016/j.fertnstert.2013.03.007) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions