From: Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina Invest. Ophthalmol. Vis.

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Invest. Ophthalmol. Vis. Sci ;48(10): doi: /iovs Figure Legend:

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From: Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina Invest. Ophthalmol. Vis. Sci.. 2015;56(8):4413-4424. doi:10.1167/iovs.14-16250 Figure Legend: Quantification of levels of D-Cy5 in posterior eye cups by fluorescence spectroscopy, after extraction of D-Cy5 from tissue. (A) Levels of dendrimers in non-I/R eyes show significant differences from those in I/R eyes after a single intravitreal injection of 20 μg D-Cy5. (B) D-Cy5 levels after a single IV injection of 600 μg; (C) comparison of dendrimer levels in I/R eyes in both the intravitreal and IV routes (at 30× higher dose) are comparable (n = 8; Student's t-test). For quantification, posterior eye cups were homogenized and lyophilized, and dendrimers were extracted into a small volume of methanol. Fluorescence was measured using previously established protocols, with appropriate D-Cy5 calibration and controls. D-Cy5 was near detection limit (NDL) in healthy eyes (3 and 21 days). *P < 0.01, I/R compared to non-I/R. Date of download: 10/12/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.