Serum Hepatitis B Surface Antigen Quantitation Can Reflect Hepatitis B Virus in the Liver and Predict Treatment Response  Henry Lik–Yuen Chan, Vincent Wai–Sun Wong, Ada Mei–Ling Tse, Chi–Hang Tse, Angel Mei–Ling Chim, Hoi–Yun Chan, Grace Lai– Hung Wong, Joseph Jao–Yiu Sung  Clinical Gastroenterology and Hepatology  Volume 5, Issue 12, Pages 1462-1468 (December 2007) DOI: 10.1016/j.cgh.2007.09.005 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Scatter plot with best-fit line of (A) HBsAg and log [cccDNA] and (B) HBsAg and log [intrahepatic HBV DNA] at baseline. (A) r = 0.54, P = .004; (B) r = 0.43, P = .028. Clinical Gastroenterology and Hepatology 2007 5, 1462-1468DOI: (10.1016/j.cgh.2007.09.005) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Scatter plot with best-fit line of (A) HBsAg and log [cccDNA] and (B) HBsAg and log [intrahepatic HBV DNA] at end of treatment. (A) r = 0.29, P = .15; (B) r = 0.44, P = .025. Clinical Gastroenterology and Hepatology 2007 5, 1462-1468DOI: (10.1016/j.cgh.2007.09.005) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Scatter plot with best-fit line of (A) reduction of HBsAg and reduction of log [cccDNA] and (B) reduction of HBsAg and reduction of log [intrahepatic HBV DNA]. (A) r = 0.68, P ≤ .0001; (B) r = 0.65, P ≤ .0001. Clinical Gastroenterology and Hepatology 2007 5, 1462-1468DOI: (10.1016/j.cgh.2007.09.005) Copyright © 2007 AGA Institute Terms and Conditions

Figure 4 ROC curve of baseline HBsAg (solid line) and log [serum HBV DNA] (dashed line) for sustained virologic response. Area under ROC curve for HBsAg was 0.80 (95% CI, 0.62–0.98; P = .022). Area under ROC curve for log [serum HBV DNA] was 0.39 (95% CI, 0.14–0.64; P = .40). Clinical Gastroenterology and Hepatology 2007 5, 1462-1468DOI: (10.1016/j.cgh.2007.09.005) Copyright © 2007 AGA Institute Terms and Conditions