Britta Torgrimson-Ojerio, Rebecca L. Ross, Nathan F

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Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia Britta Torgrimson-Ojerio, Rebecca L. Ross, Nathan F. Dieckmann, Stephanie Avery, Robert M. Bennett, Kim D. Jones, Anthony J. Guarino, Lisa J. Wood Journal of Neuroimmunology Volume 277, Issue 1, Pages 160-167 (December 2014) DOI: 10.1016/j.jneuroim.2014.10.003 Copyright © 2014 The Authors Terms and Conditions

Fig. 1 Neuroendocrine response during exercise. Serum levels of ACTH, GH, and cortisol in FM (open circle) and HCs (closed square) collected at pre-exercise (Pre), at VO2 peak (Peak), and 1-hour after VO2 peak (Post). Each data point represents the mean±SEM. Serum analyte data were not normally distributed and so data was subjected to logarithmic transformation (Ln) before all statistical analyses. A two (FM vs. HC)×3 (pre-, peak-, and post-exercise) repeated measure ANOVA was used to analyze differences in exercise-induced changes in serum neuroendocrine and inflammatory analytes and PPT between FM and HCs. Both linear and quadratic contrasts were tested on the time effect. Journal of Neuroimmunology 2014 277, 160-167DOI: (10.1016/j.jneuroim.2014.10.003) Copyright © 2014 The Authors Terms and Conditions

Fig. 2 Inflammatory cytokine response during and after exercise. Serum levels of IL-6, IL-10, TNF-α, and IL-8 in FM (open circle) and HCs (closed square) collected at pre-exercise (pre), at VO2 peak (peak), 1-hour after VO2 peak (Post), 2-days after exercise (Day 2), and 4-days after exercise (Day 4). Each data point represents the mean±SEM. Serum analyte data were not normally distributed and so data was subjected to logarithmic transformation (Ln) before all statistical analyses. A 2 (FM vs. HC)×3 (pre-, peak-, and post-) and repeated measure ANOVA was used to analyze differences in exercise-induced changes during exercise, and a 2 (FM vs. HC)×3 (pre-, Day 2, and Day 4) repeated measure ANOVA was used to analyze differences in post-exertional changes in each inflammatory analyte. Journal of Neuroimmunology 2014 277, 160-167DOI: (10.1016/j.jneuroim.2014.10.003) Copyright © 2014 The Authors Terms and Conditions

Fig. 3 Post-exertional pain, tenderness, fatigue and stiffness. A) Post-exertional changes in local pain and tenderness in the upper thigh muscles using the pain pressure threshold test (PPT) before exercise (pre) and then 2-days (Day 2) and 4-days after exercise (Day 4) in FM (open circles) and HCs (closed squares). Each data point represents the mean±SEM. A two (FM vs. HC)×3 (pre-, Day 2, and Day 4) repeated measure ANOVA was used to analyze differences in exercise-induced changes in PPT between FM and HCs. B) Exercise-induced change in fatigue, and stiffness calculated from pre- and post-exercise FIQR/SIQR scores in FM (open bars) and HCs (closed bars). Each bar represents the mean change scores±SEM. The asterisk represents a p<.05. Journal of Neuroimmunology 2014 277, 160-167DOI: (10.1016/j.jneuroim.2014.10.003) Copyright © 2014 The Authors Terms and Conditions