A cumulative analogue joint involvement scale (CAJIS) for fibrodysplasia ossificans progressiva (FOP) Frederick S. Kaplan, Mona Al Mukaddam, Robert J.

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A cumulative analogue joint involvement scale (CAJIS) for fibrodysplasia ossificans progressiva (FOP) Frederick S. Kaplan, Mona Al Mukaddam, Robert J. Pignolo Bone Volume 101, Pages 123-128 (August 2017) DOI: 10.1016/j.bone.2017.04.015 Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 1 CAJIS scores are correlated with age and similar between males and females. N=144 assessments. R2 (males)=0.654, R2 (females)=0.576, coefficients of determination. Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 2 CAJIS scores are significantly related to age in axial skeletal regions by 1-way ANOVA (p<0.0001for each site). Post-hoc analysis (compared to CAJIS score of 0): **, p<0.01; *, p<0.05. Cross bars indicate medians. N=144 assessments. Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 3 CAJIS scores are significantly related to age in the right upper extremity by 1-way ANOVA (p<0.0001 for each site). Post-hoc analysis (compared to CAJIS score of 0): **, p<0.01; *, p<0.05. Cross bars indicate medians. N=144 assessments. Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 4 CAJIS scores are significantly related to age in the right lower extremity by 1-way ANOVA (p<0.0001 for each site). Post-hoc analysis (compared to CAJIS score of 0): **, p<0.01; *, p<0.05. Cross bars indicate medians. N=144 assessments. Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 5 Upper extremity CAJIS score predicts ADL status. One-way ANOVA, p<0.05; Tukey post-hoc analysis Independent versus Some Assistance, p=0.001; Independent versus Total Assistance, p=0.001. Cross bars indicate medians. N=144 assessments. Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 6 Lower extremity CAJIS score predicts ambulatory status. One-way ANOVA, p<0.05; Tukey post-hoc analysis Ambulatory Exclusively versus Wheelchair As Needed, p=0.001; Ambulatory Exclusively versus Wheelchair Exclusively, p=0.001. Cross bars indicate medians. N=144 assessments. Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 7 Inter-rater correlation in the application of the CAJIS is very high. N=23; R2=0.971, coefficient of determination (p<0.0001). Bone 2017 101, 123-128DOI: (10.1016/j.bone.2017.04.015) Copyright © 2017 Elsevier Inc. Terms and Conditions