Calming the atopic dermatitis flare cycle with Protopic® VO: Atopic dermatitis is a disease of both skin barrier dysfunction and immune system hyperactivity.1,2 Super: Danby and Cork, Journal of Clinical Dermatology. 2010, 1(2):33-46 Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 VO: The stratum corneum can be thought of as a ‘brick wall’. Corneocytes are the bricks. Intercellular lipids acts as cement, while corneodesmosomes serve as iron rods embedded within the cement to stabilise the structure. 翻译： 翻译： 翻译：

VO: In normal skin, the stratum corneum serves as a protection from irritants and allergens in the environment. VO: In patients with atopic dermatitis, the stratum corneum is disrupted,2... Super: Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 VO: …allowing irritants and allergens from the environment… 翻译： 翻译： 翻译：

翻译： 翻译： 翻译： VO: …to easily penetrate.2 Super: Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 VO: Allergen penetration in turn… Super: VO: …leads to the development of an allergic response and inflammation.3 Super: Cork M et al., Journal of Investigative Dermatology (2009) 129, 1892–1908 翻译： 翻译： 翻译：

AD Skin VO: As well as having an increased susceptibility to allergen penetration, a defective skin barrier is also responsible for increased trans-epidermal water loss, leading to dry skin.5 Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. VO: In a recent study of quiescent AD patients, Protopic® has been shown to decrease trans-epidermal water loss significantly. Following treatment with Protopic®, trans-epidermal water loss improved significantly from baseline, whereas trans-epidermal water loss increased following betamethasone valerate cream treatment.6 Super: Danby et al., British Journal of Dermatology. 2014, 170:914-921 VO: This is what AD skin looks like… Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. 翻译： 翻译： 翻译：

AD Skin treated with TCS and emollients AD Skin treated with Protopic and emollients VO: A multifactorial disease requires a multifactorial approach. Atopic dermatitis treatment strategies should target both skin barrier dysfunction as well as the immune system response and inflammation. VO: TCS can work on the inflammation, and emollients help to protect the skin from the top. But long-term TCS use causes thinning of the epidermal wall, increasing trans-epidermal water loss.5,6 Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. Danby et al., British Journal of Dermatology 2014. VO: By using Protopic® and emollients together as a long-term treatment option, Protopic® works to decrease the inflammation to the same degree as with mid-potency steroids, but also supports the skin barrier. Protopic® has also been shown to significantly increase lipid lamellae in the intercellular space compared to mometasone furoate, thereby reducing trans-epidermal water loss.5 Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. 翻译： 翻译： 翻译：

TCS TCS VO: Steriods are effective for the short term. But long-term use of topical corticosteroids as treatment for AD is not ideal as it can weaken the skin barrier, allowing allergens to penetrate and thereby perpetuating the flare cycle.6 Super: Danby et al., British Journal of Dermatology 2014. VO: If you switch to Protopic® after a week of TCS treatment and to use Protopic® as a first choice for the treatment of the early signs of recurring flares, you will reduce the TCS usage in the long term. VO: Protopic® decreases trans-epidermal water loss, increases lipid lamellae and supports the skin barrier.5,6 Super: Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. Danby et al., British Journal of Dermatology. 2014, 170:914-921 翻译： 翻译： 翻译：

翻译： 翻译： 翻译： VO: …use Protopic® as a first switch after TCS … VO: Protopic® also acts on inflammation and allows the skin to protect against external triggers, preventing or minimising recurring flares.7,8,9 Super: Hanifin et al., Journal of the American Academy of Dermatology. 2005 Aug, 53(2 Suppl. 2):S186-94 Reitamo et al., Journal of Allergy and Clinical Immunology. 2002 Mar, 109:547–555 Nakagawa, Clinical Drug Investigation. 2006, 26(5):235–246 VO: …use Protopic® as a first switch after TCS … VO: Protopic® calms the flare cycle and brings control to long-term AD treatment.7,10 For a holistic and effective treatment approach… Super: Hanifin et al., Journal of the American Academy of Dermatology. 2005 Aug, 53(2 Suppl. 2):S186-94 Kapp et al., Journal of Dermatological Treatment. 2003, 14(Suppl. 1):5-16 翻译： 翻译： 翻译：

Protopic® calms the flare cycle. Protopic® supports the repair of the skin barrier and reduces inflammation. Protopic® brings control to long-term AD treatment. VO: Protopic® calms the flare cycle.3,11 Protopic® supports the repair of the skin barrier and reduces inflammation.7 Protopic® brings control to long-term AD treatment.3,11 Super: 3. Kapp et al., Journal of Dermatological Treatment. 2003, 14(Suppl. 1):5-16 11. Hanifin et al., Journal of the American Academy of Dermatology. 2005 Aug, 53(2 Suppl. 2):S186-94. TCS VO: …and as a first choice of treatment with early signs of recurring flares. 翻译： 翻译：

References: Danby and Cork, Journal of Clinical Dermatology. 2010, 1(2):33-46 Cork et al., Journal of Allergy and Clinical Immunology. 2006, 118:3-21 Cork M et al., Journal of Investigative Dermatology (2009) 129, 1892–1908 Dähnhardt-Pfeiffer et al., JDDG. 2013, 11(5):437-443. Danby et al., British Journal of Dermatology. 2014, 170:914-921 Hanifin et al., Journal of the American Academy of Dermatology. 2005 Aug, 53(2 Suppl. 2):S186-94 Reitamo et al., Journal of Allergy and Clinical Immunology. 2002 Mar, 109:547–555 Nakagawa, Clinical Drug Investigation. 2006, 26(5):235–246 Kapp et al., Journal of Dermatological Treatment. 2003, 14(Suppl. 1):5-16