Efficacy and Safety of High-dose Vitamin C on Complex Regional Pain Syndrome in Extremity Trauma and Surgery—Systematic Review and Meta-Analysis Naohiro.

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Efficacy and Safety of High-dose Vitamin C on Complex Regional Pain Syndrome in Extremity Trauma and Surgery—Systematic Review and Meta-Analysis Naohiro Shibuya, DPM, MS, FACFAS, Jon M. Humphers, DPM, Monica R. Agarwal, DPM, Daniel C. Jupiter, PhD The Journal of Foot and Ankle Surgery Volume 52, Issue 1, Pages 62-66 (January 2013) DOI: 10.1053/j.jfas.2012.08.003 Copyright © 2013 American College of Foot and Ankle Surgeons Terms and Conditions

Fig. 1 A study flow diagram. The Journal of Foot and Ankle Surgery 2013 52, 62-66DOI: (10.1053/j.jfas.2012.08.003) Copyright © 2013 American College of Foot and Ankle Surgeons Terms and Conditions

Fig. 2 A forest plot showing RR of developing CRPS when high-dose vitamin C is administered daily for each of 4 studies. A cumulative RR is also presented. For each study the number of cases of CRPS (events) in each arm is shown as compared to all patients within the arm (total). The Journal of Foot and Ankle Surgery 2013 52, 62-66DOI: (10.1053/j.jfas.2012.08.003) Copyright © 2013 American College of Foot and Ankle Surgeons Terms and Conditions

Fig. 3 Risk of bias summary: review authors' judgments about each risk of bias item for each included study. +, Low risk for bias; -, high risk. The Journal of Foot and Ankle Surgery 2013 52, 62-66DOI: (10.1053/j.jfas.2012.08.003) Copyright © 2013 American College of Foot and Ankle Surgeons Terms and Conditions