Time-courses of plasma IL-6 and HMGB-1 reflect initial severity of clinical presentation but do not predict poor neurologic outcome following subarachnoid.

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Time-courses of plasma IL-6 and HMGB-1 reflect initial severity of clinical presentation but do not predict poor neurologic outcome following subarachnoid hemorrhage Heikki Kiiski, Jaakko Långsjö, Jyrki Tenhunen, Marika Ala-Peijari, Heini Huhtala, Mari Hämäläinen, Eeva Moilanen, Juha Öhman, Jukka Peltola eNeurologicalSci Volume 6, Pages 55-62 (March 2017) DOI: 10.1016/j.ensci.2016.11.010 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 IL6 levels measured within the first 24h after aSAH in relation to the initial clinical presentation. Patients with more severe clinical presentations had significantly higher IL-6 levels (p=0.002). Black circles represent outliers. eNeurologicalSci 2017 6, 55-62DOI: (10.1016/j.ensci.2016.11.010) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 IL6 levels measured within the first 24h after aSAH in relation to clinically suspected infection during ICU follow-up. Early IL-6 levels are significantly higher in patients with infection during follow-up (p=0.031). Black circles represent outliers. eNeurologicalSci 2017 6, 55-62DOI: (10.1016/j.ensci.2016.11.010) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 IL6 levels measured within the first 24h after aSAH in relation to the severity of aSAH in primary CT. There is a trend towards higher IL-6 levels in patients with more severe CT findings but statistical significance is not reached by a narrow margin (p=0.051). Black circles represent outliers. eNeurologicalSci 2017 6, 55-62DOI: (10.1016/j.ensci.2016.11.010) Copyright © 2016 The Authors Terms and Conditions

Fig. 4 IL-6 and HMGB1 levels for patients (n=22) with the ICU follow-up lasting for five days (n=22). Circles represent individual patient values. Values are grouped into favorable and non-favorable neurological outcome. Linear regression shows no significant change between baseline values for IL-6 (mRS 0–2: p-value 0.084, beta −1.048/mRS 3–6: p-value 0.515, beta −0.879) or HMGB1 (mRS 0–2: p-value 0.454, beta 0.183/mRS 3–6: p-value 0.776, beta 0.106) during the follow-up. Outliers are not shown. eNeurologicalSci 2017 6, 55-62DOI: (10.1016/j.ensci.2016.11.010) Copyright © 2016 The Authors Terms and Conditions

Fig. 5 Scatter plots displaying the correlation of individual patient values of IL-6 against those of HGMB1 at different time points during the ICU follow-up. Outliers are not shown. eNeurologicalSci 2017 6, 55-62DOI: (10.1016/j.ensci.2016.11.010) Copyright © 2016 The Authors Terms and Conditions