Global Overview of the Microbiome: Beyond HIV Alan Landay, PhD Professor and Chairman Department of Immunology/Microbiology Rush University Medical Center Chicago, Illinois
ll 1 Lita Proctor HMP
Conflict of Interest None
Meta- bolomics
Human Microbiome Project
Particular Interest in the Virome
The Human Mycobiome
What do we know about the gut microbiome in health?
Intestinal microbiota >1014 microorganisms in GIT making us 90% bugs and 10% “us”! Microbiota=the collective microorganisms Microbiome=the collective gene content of those microorganisms “Dysbiosis”= dysregulated (abnormal) microbiota. Common to many diseases including diabetes, colon cancer, and IBD Site specific microbiota in GIT
Composition and luminal concentrations of dominant microbial species in various regions of the gastrointestinal tract. Gastroenterology 2008 134(2)
The gut microbiota during the human lifespan
The Western Microbiota Diverges from That of Non-Western Populations
What is happening in the gut in HIV ?
Therapeutic role of the Microbiome in HIV
Dillon AIDS 2016
Future Directions Studies on Metagenomics, Metatranscriptomics, Metabolomics Extend work to Virome and Mycobiome Define Interactions of Gut Microbiome with Mucosal Immune System and Epithelial Cell Biology Move beyond the Gut to Female Genital Tract, Lung, Oral, Skin, Breast Milk Microbiome
Acknowledgements University of Colorado University of Alcala Stephanie Dillon Sergio Serrano-Villar Cara Wilson