Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized.

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Presentation transcript:

Oral contraceptive use changes brain activity and mood in women with previous negative affect on the pill—A double-blinded, placebo-controlled randomized trial of a levonorgestrel-containing combined oral contraceptive Malin Gingnell, Jonas Engman, Andreas Frick, Lena Moby, Johan Wikström, Mats Fredrikson, Inger Sundström-Poromaa Psychoneuroendocrinology Volume 38, Issue 7, Pages 1133-1144 (July 2013) DOI: 10.1016/j.psyneuen.2012.11.006 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 The emotion task (A) and the sensory-motor control task (B). Participants were requested to compare the top target slide with the two lower images and indicate which one expressed the same emotion or had the same form as the target. Psychoneuroendocrinology 2013 38, 1133-1144DOI: (10.1016/j.psyneuen.2012.11.006) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Subject flow and allocation to the intervention and control conditions. Psychoneuroendocrinology 2013 38, 1133-1144DOI: (10.1016/j.psyneuen.2012.11.006) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 3 During the last week of the treatment cycle COC users had lower reactivity in the left insula than placebo users (Tailarach coordinates: −33, 22, −17, cluster size: 21voxels). Brighter colors indicate higher T-scores. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Psychoneuroendocrinology 2013 38, 1133-1144DOI: (10.1016/j.psyneuen.2012.11.006) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 4 Compared to the pretreatment cycle, women randomized to placebo had lower right amygdala reactivity during last week of treatment (Tailarach coordinates: 27, 1, −17, cluster size: 4voxels). Brighter colors indicate higher T-scores. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Psychoneuroendocrinology 2013 38, 1133-1144DOI: (10.1016/j.psyneuen.2012.11.006) Copyright © 2012 Elsevier Ltd Terms and Conditions