Volume 30, Issue 6, Pages (December 2011)

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Volume 30, Issue 6, Pages 831-837 (December 2011) Postprandial protein metabolism but not a fecal test reveals protein malabsorption in patients with pancreatic exocrine insufficiency Gheorghe Airinei, Claire Gaudichon, Cecile Bos, Cyriaque Bon, Nathalie Kapel, Bakhtiar Bejou, Jean Jacques Raynaud, Catherine Luengo, Thomas Aparicio, Philippe Levy, Daniel Tome, Robert Benamouzig Clinical Nutrition Volume 30, Issue 6, Pages 831-837 (December 2011) DOI: 10.1016/j.clnu.2011.06.006 Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Terms and Conditions

Fig. 1 Study design and metabolic test. Clinical Nutrition 2011 30, 831-837DOI: (10.1016/j.clnu.2011.06.006) Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Terms and Conditions

Fig. 2 Postprandial plasma glycemia and insulinemia without (black circles) and with (open circles) enzyme therapy. (A) Glycemia (B) Insulinemia. Results are mean ± SD (n = 6, patients not receiving insulin therapy for diabetes). The main effects (treatment, time) and their interaction were tested in a mixed model with time and treatment as repeated factors. Clinical Nutrition 2011 30, 831-837DOI: (10.1016/j.clnu.2011.06.006) Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Terms and Conditions

Fig. 3 Dietary nitrogen transfer to nitrogen metabolic pools: (A) serum amino acids, (B) serum proteins, (C) cumulated urinary urea output and (D) total deamination, without (black circles) and with (open circles) enzyme therapy. Results are mean ± SD (n = 11). The main effects (treatment, time) and their interaction were tested in a mixed model with time and treatment as repeated factors. Clinical Nutrition 2011 30, 831-837DOI: (10.1016/j.clnu.2011.06.006) Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Terms and Conditions

Fig. 4 Individual response to enzyme substitution of dietary nitrogen recovery in the metabolic pools. Clinical Nutrition 2011 30, 831-837DOI: (10.1016/j.clnu.2011.06.006) Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Terms and Conditions

Fig. 5 Relationship between steatorrhea and the difference in dietary N transferred to deamination after enzyme therapy in diabetics (gray square) and non-diabetic patients (black circles). Clinical Nutrition 2011 30, 831-837DOI: (10.1016/j.clnu.2011.06.006) Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Terms and Conditions