F60 iO2 and Advanced Modes Assaf Weiss, Product Manager www.flight-medical.com Flight Medical Confidential 1

Agenda Flight 60 Overview Introduction to Flight 60iO2 – internal blender model Advanced modes overview Volume Guarantee B-LEV (APRV)

Well known technology in an intuitive and advanced ventilator Performance Volume Guarantee Bi-Phasic Ventilation (APRV) Unlimited autonomy: 12 Hours battery life, 15lbs “...it’s the smallest that they make but at the same time the electronics allow us to do all of the types of therapy we do with a full size ventilator…” Advanced modes, size matters, dual and single limb high pressure and low flow options. Easy to use – provides you with the levels of details you need when needed (simple UI for home care, advanced for hospitals, quick-start screen for ER) Stephen Holland, M.D. Vice President and Chief Medical Officer Gaylord Specialty Healthcare , CT

Well known technology in an intuitive and advanced ventilator Versatility Paediatric to Adults Dual/Single limb High Pressure/Low Flow Oxygen Invasive and non invasive Advanced modes, size matters, dual and single limb high pressure and low flow options. Easy to use – provides you with the levels of details you need when needed (simple UI for home care, advanced for hospitals, quick-start screen for ER)

Well known technology in an intuitive and advanced ventilator Advanced modes, size matters, dual and single limb high pressure and low flow options. Easy to use – provides you with the levels of details you need when needed (simple UI for home care, advanced for hospitals, quick-start screen for ER) Simplicity 7” touch screen Ease of use/ Enhanced user interface Waveforms, loops and 72 Hours trends

Well known technology in an intuitive and advanced ventilator Performance Volume Guarantee Bi-Phasic Ventilation (APRV) Unlimited autonomy: 12 Hours battery life, 15lbs Versatility Paediatric to Adults Dual/Single limb High Pressure/Low Flow Oxygen Invasive and non invasive Advanced modes, size matters, dual and single limb high pressure and low flow options. Easy to use – provides you with the levels of details you need when needed (simple UI for home care, advanced for hospitals, quick-start screen for ER) Simplicity 7” touch screen Ease of use/ Enhanced user interface Waveforms, loops and 72 Hours trends

99% Success, meet all clinical needs Trauma COPD ARDS Neuromuscular Pulmonary Edema Spinal Cord Injury Lung Cancer

1200 beds, 40 F60s, 100% satisfaction Successfully integrated into 10 sub-acute wards Adapted by ER staffs as main ventilator In-hospital transport – Only Flight 60

Active mobilization with Flight 60 Bedside: PB840 Transport: Flight 60 “...it’s the smallest that they make but at the same time the electronics allow us to do all of the types of therapy we do with a full size ventilator…” Stephen Holland, M.D. Vice President and Chief Medical Officer

ER & Internal transport Emergency Preparedness Continuity of Care 1 ventilator meets multiple ventilation needs EMS Acute Care Hospital ICU & Step down units ER & Internal transport LTACH Emergency Preparedness Long Term/SNF Home Care Flight Medical Confidential 10

F60 iO2 Internal Blender and Advance Modes www.flight-medical.com Flight Medical Confidential 11

F60 iO2 with advanced modes Internal blender, electronically controlled => Improved accuracy and portability, easy to use, safer Volume Guarantee Mode => Improves patient ventilation and safety by adjusting to changes in: Progression of the disease Body position and sleep stages B-LEV (APRV) Mode => ARDS patient management, transport sever cases with the F60 without compromising performance.

Front and Back Panels Front: Nebulizer port Back: DISS high pressure connector

Parameter Screens When O2 Mixer is enabled and nebulizer is disabled: When O2 Mixer is disabled:

Extended Screen

Service Screen – Configuration* Enable Internal O2 Mixer Enable VG mode Enable B-LEV Disable Nebulizer * Factory default for US customers

Additional O2 Features %O2 control 2 minutes 100% O2

Additional Alarms VG Mode: Target Volume Not Reached O2 Supply Failed Check O2 Sensor O2 Leak Additional oxygen analyzer for detecting internal leaks

F60 Advanced Modes www.flight-medical.com 19 Flight Medical Confidential 19

“best of volume control ventilation and pressure control ventilation” Volume Guarantee Volume Guarantee is pressure mode with a guaranteed volume by using a targeted tidal volume with an optional minimum preset rate (MVG) to provide a minimum minute volume. “best of volume control ventilation and pressure control ventilation”

Volume Guarantee “the right pressure at the right time” ± 1 to 2 cmH2O every 5 breaths Pressure PEEP Target Vt Pressure Change = Missing volume X [Average Pressure / Average Volume]

Volume Guarantee Sub-Modes VtG: Tidal Volume Guarantee: spontaneous mode MVG: Minute Volume Guarantee: spontaneous with back-up rate

Volume Guarantee Mode Volume Guarantee adapts to short term patient changing needs (due to sleep stages, body position) and longer term changes such as disease progression to ensure efficacy together with greater comfort of ventilation

VtG (Tidal Volume Guarantee) Spontaneous Only In VtG mode, the target volume is reached by controlling the pressure support applied to the patient based on three parameter settings: Target VtG – The target tidal volume. PSV min – The minimum pressure allowed by the operator. PSV max – The maximum pressure allowed by the operator.

MVG (Minute Volume Guarantee) In MVG mode, when the patient fails to trigger a breath within the interval determined by the Rate control, the ventilator triggers a mandatory breath with a set Ti. The Rate, in combination with the Target VtG setting, determines the minimum delivered minute volume. Target VtG – The target tidal volume. PSV min – The minimum pressure that can be applied. PSV max – The maximum pressure that can be applied. Rate – The minimum rate (determines the interval). Ti – The inspiratory time of the mandatory breaths.

Trigger Delay In MVG mode, Trigger Delay function doubles the delay time before mandatory (time cycled) ventilation is activated.

Trigger Delay When Trigger Delay is set to OFF Delay = 60/Rate When Trigger Delay is set to ON Delay = 2 * 60/Rate

Trigger Delay Benefits Encourages spontaneous breathes - Improved weaning  Eliminates frequent switching between patient triggered/time triggered breathes – enhanced patient synchronization  

Flight 60 – MVG Quick Guide Step 1: Set the Extended screen Parameters TRENDS ON PSV Flow Term 15 VG Mode MVG Descent

Flight 60 – MVG Quick Guide Step 2: Set the Home screen Parameters PSV min 10 PSV max 30 0.8 Target VtG 400 MVG

Flight 60 B-LEV mode The ventilator cycles between two different baseline pressures based on time. Patient is allowed to breathe spontaneously at both the high and low pressure baselines.

Flight 60 B-LEV mode

Flight 60 B-LEV mode Controls specific to B-LEV:

Flight 60 B-LEV mode Controls specific to B-LEV:

Understanding F60 Modes Controlled (mandatory) Modes Supported (spontaneous) Modes Combined (mixed) Modes Spontaneous Breathing (CPAP)

Understanding F60 Modes Controlled (mandatory) Modes Supported (spontaneous) Modes Combined (mixed) Modes Spontaneous Breathing (CPAP) ACMV - PC SPONT + PS SIMV – PC SPONT with PSV = 0 ACMV – VC VtG SIMV - VC MVG B-LEV

F60 iO2 and Advanced Modes Assaf Weiss, Product Manager www.flight-medical.com Flight Medical Confidential 37