Date of download: 10/13/2017 Copyright © ASME. All rights reserved. From: Thermally Induced Apoptosis, Necrosis, and Heat Shock Protein Expression in Three-Dimensional Culture J Biomech Eng. 2014;136(7):071006-071006-10. doi:10.1115/1.4027272 Figure Legend: HSP70 induction in 2D and 3D cultures of PC3 cells at 44 °C and 45 °C for 120 min. The difference in HSP70 induction between the 2D and 3D culture was found to be statistically significant for heating at 45 °C for 120 min (n = 3, t-test p < 0.001).