Pathophysiologic events in a gouty joint

Slides:



Advertisements
Similar presentations
ACLS algorithm for bradycardia
Advertisements

Adhesive capsulitis of the shoulder
(Modified from Hanley NA, Arlt W
Denture stomatitis caused by candida in a patient wearing a "flipper" (temporary removable denture to replace a missing tooth). Source: Diseases of the.
(Adapted, with permission, from Fagin JA
The tracing shown was observed at EP study in a young man without evidence of heart disease. What is the likely mechanism of tachycardia for both the narrow.
Electrocardiogram of a patient with hyperkalemia
Prostanoid mediators derived from arachidonic acid and sites of drug action. ASA, acetylsalicylic acid (aspirin); LT, leukotriene; NSAID, nonsteroidal.
Actions of Leukotriene Antagonists and Corticosteroids
ACLS algorithm for asystole
Pathophysiology of esophageal reflux disease
In certain patients with the long QT syndrome, potassium channel function is reduced (diagonal arrows), which leads to prolongation of the action potential.
Virtual integration involves contractual links between HMOs and physician groups, hospitals, and other provider units. Source: How Health Care Is Organized—II:
Diagnostic approach: Dizziness.
Stages in the development of type 2 DM from a pre-diabetic, insulin-resistant state. As insulin sensitivity decreases, insulin-mediated glucose disposal.
Complement reaction sequence and infections associated with deficiency states. (Redrawn, with permission, from Nairn R. Immunology. In: Brooks GF et al,
(Reproduced, with permission, from Findling JW, et al
Pathogenesis of bone diseases in chronic kidney disease
A simplified diagram of smooth muscle contraction and the site of action of calcium channel-blocking drugs. Contraction is triggered (red arrows) by influx.
Treatment approaches for Crohn disease. (Adapted from Hemstreet BA
Treatment algorithm for hyperuricemia in gout
PICC line thrombus (arrow) with 2D (A) and 3D (B) imaging.
Nine patterns of inflammatory skin disease. (See also Table 8–1.)
My Treatment Approach to Gout
Diagnostic algorithm for normocytic anemia.
(Reproduced, with permission, from Findling JW
The relationship among infection, sepsis, and the systemic inflammatory response syndrome (SIRS). (Modified from the American College of Chest Physicians/Society.
The amine hypothesis of major depression
Diffuse neurotransmitter pathways in the CNS
Using the prosthesis as an assisting hand
Metabolism of ethanol by alcohol dehydrogenase (ADH) and the microsomal ethanol-oxidizing system (MEOS). Alcohol dehydrogenase and aldehyde dehydrogenase.
Oral contraceptive pill hormonal components
Effects of three antiseizure drugs on sustained high-frequency firing of action potentials by cultured neurons. Intracellular recordings were made from.
Schematic representation of the hypothesized pathway between maternal or intrauterine infection and preterm birth or periventricular leukomalacia. Both.
Algorithm for pain management in oncology patients
Cartoon illustrating the nonsuperimposibility of the two stereoisomers of carvedilol on the β receptor. The "receptor surface" has been grossly oversimplified.
In diastolic dysfunction, the diastolic pressure-volume relationship is shifted upward and to the left (dashed line), which leads to an elevated left ventricular.
[From Pansky B: Review of Gross Anatomy, 6th ed
Development of transfusion-related acute lung injury (TRALI) following blood transfusion. A. Pre transfusion; B. Post-transfusion showing rapid emergence.
Midsagittal section through the brain of a patient with a brain stem tumor. Histologic findings showed the tumor to be an ependymoma. Source: Discussion.
Proposed pathogenesis of inflammatory bowel disease and target sites for pharmacological intervention. Shown are the interactions among bacterial antigens.
Spleen. Illustration showing the relationship of the splenic blood supply to the white pulp and the red pulp. (From Robbins Pathologic Basis of Disease,
Schematic diagram comparing some anatomic and neurotransmitter features of autonomic and somatic motor nerves. Only the primary transmitter substances.
The fraction of drug absorbed using the Wagner–Nelson method may be used to distinguish between the first-order drug absorption rate of a conventional.
Bioavailability of a drug from an immediate-release tablet containing 50 mg of drug given at 0, 4, and 8 hours compared to a single 150-mg drug dose given.
The fraction of drug absorbed using the Wagner–Nelson method may be used to distinguish between the first-order drug absorption rate of a conventional.
Schematic illustration of a generalized cholinergic junction (not to scale). Choline is transported into the presynaptic nerve terminal by a sodium-dependent.
Illustration of ways regression lines can differ
A model of the interaction of a steroid, S (eg, cortisol), and its receptor, R, and the subsequent events in a target cell. The steroid is present in the.
Effects of active metabolites of vitamin D (D), parathyroid hormone (PTH), calcitonin (CT), and fibroblast growth factor 23 (FGF23) on calcium and phosphorus.
Mechanism of action of cocaine and amphetamine on synaptic terminal of dopamine (DA) neurons. Left: Cocaine inhibits the dopamine transporter (DAT), decreasing.
Normal glomerular autoregulation serves to maintain intraglomerular capillary hydrostatic pressure, glomerular filtration rate (GFR), and, ultimately,
The action of xanthine oxidase in uric acid synthesis and metabolism of allopurinol. (Modified and reproduced, with permission, from Katzung BG, editor:
(Adapted and reprinted with permission, from Hughes JM et al: Effect of lung volume on the distribution of pulmonary blood flow in man. Respir Physiol.
Treatment algorithm for adult cardiopulmonary arrest: advanced cardiac life support (ACLS) Source: Chapter 18. Cardiac Arrest, Pharmacotherapy: A Pathophysiologic.
Absorption, transport, and storage of iron
Number of uninsured persons in the United States, 1980 to 2014 (U. S
Clinical and pathologic effects of hepatocellular failure, which commonly results from conditions associated with acute or chronic necrosis of liver cells.
Hypothalamic-pituitary-thyroid axis
PHM Fall 2016 Coordinator: Dr. Jeffrey Henderson
My Treatment Approach to Gout
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Low-dose glucocorticoid chronotherapy in rheumatoid arthritis (RA) include the night-time-release prednisone, a timing drug release formulation with administration.
The effects of prostanoids on vasculature and blood cells; a variety of vascular cells, platelets and leukocytes have been identified as targets for the.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Key functions of eosinophils (Eo) in resolution of inflammation in asthma. Key functions of eosinophils (Eo) in resolution of inflammation in asthma. Eosinophils.
Presentation transcript:

Pathophysiologic events in a gouty joint Pathophysiologic events in a gouty joint. Synoviocytes phagocytose urate crystals and then secrete inflammatory mediators, which attract and activate polymorphonuclear leukocytes (PMN) and mononuclear phagocytes (MNP) (macrophages). Drugs active in gout inhibit crystal phagocytosis and polymorphonuclear leukocyte and macrophage release of inflammatory mediators. PG, prostaglandin; IL-1, interleukin-1; LTB4, leukotriene B4. Source: Chapter 36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout, Basic & Clinical Pharmacology, 12e Citation: Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacology, 12e; 2012 Available at: https://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/Books/katz12/katz12_c036f005.png&sec=45770499&BookID=388&ChapterSecID=45764259&imagename= Accessed: October 13, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com. Inc. All rights reserved.