Example of the storage location of the sample folder Attention The demonstration uses sample data installed on your PC along with AIST-MeRAM. So, even if you don’t have any data at hand, you can start risk assessment with AIST-MeRAM. As shown below, sample data are normally stored in the folder of your choice. e.g. Computer -> Local Disk (C:) -> Program Files (x86) -> AIST-MeRAM_ENG -> SAMPLEDATA Example of the storage location of the sample folder

Demonstration of Batch Assessment Using AIST-MeRAM Risk Assessment by Batch Mode Determining the Priority Level of Risk Assessment by Substances (CSCL Screening Level Risk Assessment) 11 Sample Substances: Carbon Disulfide, Nonylphenol, LAS, Formaldehyde, Zinc, Chloroform, Tetrachloroethylene, Pyrocatechol, Benzene, Terephthalic acid, Nitrophenol)

Batch Assessment Exposure Assessment Hazard Assessment Risk Assessment 2012/8/31 Batch Assessment Exposure Assessment Hazard Assessment Risk Assessment Risk Management

Batch Assessment (exposure assessment) Step 1/9 Select “Batch Assessment” Select “Create New File” Select “Exposure Assessment” in Assessment Steps.

Batch Assessment (exposure assessment) Step 2/9 Upload a list of chemical substances for batch assessment. The sample list is normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.

Batch Assessment (exposure assessment) Step 3/9 Check the uploaded list of substances for batch assessment

Batch Assessment (exposure assessment) Step 4/9 Check physical property information (whether applicable to “Polymer” or “Readily biodegradable”) of each substance, extracted from the uploaded substance list.

Batch Assessment (exposure assessment) Step 5/9 Upload a list of CSCL notification information for batch assessment. The list is normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.

Batch Assessment (exposure assessment) Step 6/9 List of uploaded information

Batch Assessment (exposure assessment) Step 7/9 Check data/output settings.

Batch Assessment (exposure assessment) Step 8/9 Hazard assessment results for 11 target substances are displayed.

Batch Assessment (exposure assessment) Step 9/9 Exposure assessment result for benzene Total emission and exposure class Emissions by life cycle stage & usage

Batch Assessment Exposure Assessment Hazard Assessment Risk Assessment 2012/8/31 Batch Assessment Exposure Assessment Hazard Assessment Risk Assessment Risk Management

Batch Assessment (hazard assessment) Step 1/10 2012/8/31 Batch Assessment (hazard assessment) Step 1/10 Go back to the Assessment Steps window by clicking the red square button. Select “Hazard Assessment”. Select “Create New File”

Batch Assessment (hazard assessment) Step 2/10 Upload a list of chemical substances for batch assessment. The sample list is normally stored in “Programs Files (X86)” -> “AIST-MeRAM_ENG” -> “SAMPLE” on C drive.

Batch Assessment (hazard assessment) Step 3/10 Check the uploaded list of target substances.

Batch Assessment (hazard assessment) Step 4/10 Check physical property information (amine or non-amine) of each substance, extracted from the uploaded substance list.

Batch Assessment (hazard assessment) Step 5/10 Select toxicity test databases used for hazard assessment.

Batch Assessment (hazard assessment) Step 6/10 Select a reliability level of toxicity data for hazard assessment.

Batch Assessment (hazard assessment) Step 7/10 Check data/output settings.

Batch Assessment (hazard assessment) Step 8/10 Hazard assessment results for 10 out of 11 target substances are displayed.

Batch Assessment (hazard assessment) Step 9/10 Hazard assessment results for 1out of 1 target substances are displayed.

Batch Assessment (hazard assessment) Step 10/10 Hazard assessment result for benzene Hazard class, PNEC, uncertainty factor and lowest toxicity value used for PNEC derivation Toxicity　data

Batch Assessment (risk assessment ) 2012/8/31 Batch Assessment (risk assessment ) Hazard Assessment Exposure Assessment Risk Assessment Risk Management

Batch Assessment (risk assessment) Step 1/5 Select “Risk Assessment” in Assessment Steps. Go back to the Assessment Steps window by clicking the red square button. Select “Create New File”.

Batch Assessment (risk assessment) Step 2/5 List of possible risk assessment combinations (hazard and exposure assessment results) is automatically displayed by the tool.

Batch Assessment (risk assessment) Step 3/5 Risk assessment results for each substance are displayed. For comparison of data, you can compile risk assessment results in one single file using report generation functions.

Batch Assessment (risk assessment) Step 4/5 Select a type of report you want to generate. For this demonstration, select “List of screening-level assessment results by substance”. - Example of using report generation function - List of risk assessment results is automatically displayed by the tool. Select files you want to include in the report.

Batch Assessment (risk assessment) Step 5/5 - Example of using report generation function - Comparison of risk assessment results (report sample) Substances with “High” and “Medium” priority level are designated as “Priority Assessment Chemical Substances”. Substances with “Low” and “Out of classification” priority level are acceptable.

Batch Assessment (risk management) Finally, risk management is performed, based on risk assessment results. Hazard Assessment Exposure Assessment Risk Assessment Risk Management

Batch Assessment (risk management) 1/7 Select “Risk Management” in Assessment Steps. Go back to the Assessment Steps window by clicking the red square button.

Batch Assessment (risk management) 2/7 Select “Ranking type” for generate risk rankings. Select “Risk ranking” for risk management List of risk assessment results is automatically displayed by the tool. Select files you want to include in the generate risk rankings.

Batch Assessment (risk management) 3/7 Risk rankings result Substances with “Low” and “Out of classification” priority level are acceptable. Substances with “High” and “Medium” priority level are designated as “Priority Assessment Chemical Substances”.

Batch Assessment (risk management) 4/7 Select “Risk Management” in Assessment Steps. Go back to the Assessment Steps window by clicking the red square button.

Batch Assessment (risk management) 5/7 Select “Risk management options” for risk management Select a risk assessment file of a priority assessment chemical substance for risk management

Batch Assessment (risk management) 6/7

Batch Assessment (risk management) 7/7 Finish Yes No Finish

Example of the storage location of the sample folder Attention The demonstration uses sample data installed on your PC along with AIST-MeRAM. So, even if you don’t have any data at hand, you can start risk assessment with AIST-MeRAM. As shown below, sample data are normally stored in the folder of your choice. e.g. Computer -> Local Disk (C:) -> Program Files (x86) -> AIST-MeRAM_ENG -> SAMPLEDATA Example of the storage location of the sample folder