Early prednisone therapy in Henoch-Schönlein purpura: A randomized, double-blind, placebo-controlled trial Jaana Ronkainen, MD, Olli Koskimies, MD, Marja.

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Presentation transcript:

Early prednisone therapy in Henoch-Schönlein purpura: A randomized, double-blind, placebo-controlled trial Jaana Ronkainen, MD, Olli Koskimies, MD, Marja Ala-Houhala, MD, Marjatta Antikainen, MD, Jussi Merenmies, MD, Jukka Rajantie, MD, Timo Örmälä, MD, Juha Turtinen, MSc, Matti Nuutinen, MD The Journal of Pediatrics Volume 149, Issue 2, Pages 241-247 (August 2006) DOI: 10.1016/j.jpeds.2006.03.024 Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 1 Trial profile. The Journal of Pediatrics 2006 149, 241-247DOI: (10.1016/j.jpeds.2006.03.024) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 2 Disappearance of abdominal and joint symptoms, by treatment group. (a) Disappearance of abdominal symptoms; solid line, placebo (n = 19); dashed line, prednisone (n = 13). (b) Disappearance of joint symptoms; solid line, placebo (n = 30); dashed line, prednisone (n = 32). The Journal of Pediatrics 2006 149, 241-247DOI: (10.1016/j.jpeds.2006.03.024) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 3 Renal involvement after treatment in HSP patients with mild renal symptoms in the acute phase, by treatment group (36 in the prednisone group and 35 in the placebo group). P values, differences for proportions, and their 95% CIs in the resolution of renal symptoms are given above the columns for each control visit (1, 3, and 6 months). Grey bar, placebo; white bar, prednisone. The Journal of Pediatrics 2006 149, 241-247DOI: (10.1016/j.jpeds.2006.03.024) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 4 Renal signs after treatment, by treatment group. Treatment was provided for the first 28 days. (a) All patients; solid line, placebo (n = 87); dashed line, prednisone (n = 84). (b) Patients with mild renal symptoms at inclusion; solid line (n = 16); dashed line, prednisone (n = 16). (c) Patients >6 years; solid line, placebo (n = 41); dashed line, prednisone (n = 46). (d) Patients >6 years with mild renal symptoms at inclusion; solid line, placebo (n = 11); dashed line, prednisone (n = 10). The Journal of Pediatrics 2006 149, 241-247DOI: (10.1016/j.jpeds.2006.03.024) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 5 NNT figures for early prednisone treatment for HSP with 95% confidence intervals for NNT and described as NNH and NNB. See the text for details. The Journal of Pediatrics 2006 149, 241-247DOI: (10.1016/j.jpeds.2006.03.024) Copyright © 2006 Mosby, Inc. Terms and Conditions