Volume 16, Issue 8, Pages (August 2017)

Slides:

Advertisements

Similar presentations

Food systems, nutrition, health and the environment

Advertisements

Volume 11, Issue 4, Pages (April 2012)

The Lancet Public Health

Effect of a bereavement support group on female adolescents' psychological health: a randomised controlled trial in South Africa Prof Tonya Renee Thurman,

Volume 376, Issue 9734, Pages (July 2010)

Total and cause-specific mortality before and after the onset of the Greek economic crisis: an interrupted time-series analysis Ioannis Laliotis, PhD,

Demographic and practice factors predicting repeated non-attendance in primary care: a national retrospective cohort analysis David A Ellis, PhD, Ross.

The commercial determinants of health

Volume 383, Issue 9936, Pages (June 2014)

The effect of community-based support for caregivers on the risk of virological failure in children and adolescents with HIV in Harare, Zimbabwe (ZENITH):

Author gender in The Lancet journals

The impact of megacities on health: preparing for a resilient future

Volume 376, Issue 9734, Pages (July 2010)

Assessment of progress towards universal health coverage for people with disabilities in Afghanistan: a multilevel analysis of repeated cross-sectional.

Volume 13, Issue 3, Pages (March 2012)

Mental health indicators associated with oil spill response and clean-up: cross-sectional analysis of the GuLF STUDY cohort Richard K Kwok, PhD, John.

Volume 16, Issue 8, Pages (August 2017)

Threats to human health by great ocean garbage patches

Household energy and health: where next for research and practice?

Volume 388, Issue 10052, Pages (October 2016)

Volume 389, Issue 10065, Pages (January 2017)

Volume 12, Issue 9, Pages (September 2013)

Do air quality alerts benefit public health? New evidence from Canada

Volume 389, Issue 10071, Pages (February 2017)

Efficacy of chlorhexidine application to umbilical cord on neonatal mortality in Pemba, Tanzania: a community-based randomised controlled trial Dr Sunil.

Volume 388, Issue 10061, Pages (December 2016)

Volume 3, Issue 2, Pages (February 2016)

Volume 372, Issue 9642, Pages (September 2008)

Effective cross-sector collaborations create sustainability

Effect of water quality, sanitation, hand washing, and nutritional interventions on child development in rural Bangladesh (WASH Benefits Bangladesh):

Effect of provision of home-based curative health services by public sector health-care providers on neonatal survival: a community-based cluster-randomised.

Volume 4, Issue 2, Pages (February 2017)

The effect of explosive remnants of war on global public health: a systematic mixed- studies review using narrative synthesis Alexandra Frost, MSc, Prof.

Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled.

Smartphone-based screening for visual impairment in Kenyan school children: a cluster randomised controlled trial Hillary K Rono, MMed, Andrew Bastawrous,

Volume 375, Issue 9732, Pages (June 2010)

Volume 4, Issue 6, Pages (June 2017)

Malebona Precious Matsoso, Jeanette Rebecca Hunter, Vishal Brijlal

Food systems, nutrition, health and the environment

Sherif M Abdalla, Robert Bortolussi, Noni E MacDonald

Measuring health and economic wellbeing in the Sustainable Development Goals era: development of a poverty-free life expectancy metric and estimates for.

Risk of poor development in young children in low-income and middle-income countries: an estimation and analysis at the global, regional, and country.

Person-centred maternity care in low-income and middle-income countries: analysis of data from Kenya, Ghana, and India Patience A Afulani, PhD, Beth.

Volume 388, Issue 10056, Pages (October 2016)

Volume 5, Issue 8, Pages (August 2018)

Volume 17, Issue 2, Pages (February 2018)

Effect of a bereavement support group on female adolescents' psychological health: a randomised controlled trial in South Africa Prof Tonya Renee Thurman,

Tobacco use and second-hand smoke exposure in young adolescents aged 12–15 years: data from 68 low-income and middle-income countries Prof Bo Xi, PhD,

Volume 392, Issue 10163, Pages (December 2018)

Effect of a workplace-based group training programme combined with financial incentives on smoking cessation: a cluster-randomised controlled trial Floor.

Elder abuse prevalence in community settings: a systematic review and meta-analysis Yongjie Yon, MA, Christopher R Mikton, PhD, Zachary D Gassoumis, PhD,

Volume 13, Issue 12, Pages (December 2014)

Thank you to our diverse (but not diverse enough) reviewers

Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled.

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial Dr David Preiss, PhD, Suzanne M Lloyd,

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study Sarah.

Volume 6, Issue 3, Pages (March 2019)

Matthieu J Guitton The Lancet Planetary Health

Spatial lifecourse epidemiology

Effect of a behaviour change intervention on the quality of peri-urban sanitation in Lusaka, Zambia: a randomised controlled trial James B Tidwell, PhD,

Volume 5, Issue 1, Pages (January 2018)

The Lancet Global Health

The effect of the Alive & Thrive initiative on exclusive breastfeeding in rural Burkina Faso: a repeated cross-sectional cluster randomised controlled.

Deriving a practical framework for the evaluation of health apps

Refining treatment choices for ADHD

Volume 5, Issue 6, Pages (June 2018)

Chat-based instant messaging support integrated with brief interventions for smoking cessation: a community-based, pragmatic, cluster-randomised controlled.

Institutional challenges to achieving health equity in Ecuador

Sickle cell disease: a new era

Volume 18, Issue 9, Pages (September 2019)

Presentation transcript:

Volume 16, Issue 8, Pages 591-600 (August 2017) Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial Dennis Chan, PhD, Sophie Binks, MRCP, Jennifer M Nicholas, PhD, Prof Chris Frost, MA, M Jorge Cardoso, PhD, Prof Sebastien Ourselin, PhD, David Wilkie, MA, Richard Nicholas, PhD, Dr Jeremy Chataway, PhD The Lancet Neurology Volume 16, Issue 8, Pages 591-600 (August 2017) DOI: 10.1016/S1474-4422(17)30113-8 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Trial profile The Lancet Neurology 2017 16, 591-600DOI: (10.1016/S1474-4422(17)30113-8) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Percentage of patients impaired in each measure at baseline in both groups combined Numerators and denominators used to calculate these percentages are provided in the appendix (p 8). WASI=Wechsler Abbreviated Scale of Intelligence. IQ=intelligence quotient. BMIPB=Birt Memory and Information Processing Battery. VOSP=Visual Object and Space Perception. HRQoL=health-related quality of life. MCS=mental component score. PCS=physical component score. The Lancet Neurology 2017 16, 591-600DOI: (10.1016/S1474-4422(17)30113-8) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Change in cognitive scores, neuropsychiatric scores, and health-related quality of life between baseline and 24 months in both groups combined Bars are 95% CIs. In all tests, except HAM-D and NPIQ, a positive change suggests improvement. WASI=Wechsler Abbreviated Scale of Intelligence. IQ=intelligence quotient. BMIPB=Birt Memory and Information Processing Battery. VOSP=Visual Object and Space Perception. HAM-D=Hamilton Depression Rating Scale. NPIQ=Neuropsychiatric Inventory Questionnaire. HRQoL=health-related quality of life. MCS=mental component score. PCS=physical component score. *T score. The Lancet Neurology 2017 16, 591-600DOI: (10.1016/S1474-4422(17)30113-8) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions