Figure 1. Representative example of the pattern of oxygen consumption for assessment of mitochondrial function. The dashed line represents values from.

Slides:

Advertisements

Similar presentations

Schematic of the single variant polymorphism (SNP) genotyping assay.

Advertisements

From: An open day in the metric space

Figure 5. The relationship between hepatic lymphocyte subsets, hepatosteatosis and perisinusoidal fibrosis. Hepatosteatosis was associated with ( a )

Figure 6. Biochemical analysis of mTORC1- and mTORC2-dependent signaling in response to UVB. iRicKO cells were treated with vehicle or with 4OHT for 3.

Figure 4. The distribution of biology teacher main assignments

Figure 1. Heat Map Summarizing Question Types by Agency

Fig. 1. Schematic overview of diffusion maps embedding

Figure 2— Cntnap2 knockout (KO) rats exhibit seizures

From: The World Price of Credit Risk

Figure 1. Flow diagram of participants recruited into the study.

Figure 3. Day 2 cell symmetry

Figure 1. Overexpression of Kiss1r- or Adcyap1r-expressing vectors in LβT2 cells. LβT2 cells were transfected with 2.0 μg of Kiss1r-expressing (A) or Adcyap1r-expressing.

Fig 2 Task related processing times of naïve operators (blue) and experienced operators (orange) given for the four anaesthesia ventilators in the order.

Figure 1 Cumulative chance of pregnancy according to age at initiation of pregnancy seeking. The curves were drawn based on the following assumptions:

Figure 1. The Modified Dual Pathway Model.

Figure 1. Schematic diagram of the animal model used to generate intercaruncular endometria from heifers (n = 4), and lactating (n = 5), and nonlactating.

Figure 3. Average response time by signal-to-noise ratio (SNR), group, and condition. Error bars represent standard error. Response time was measured as.

Fig. 1. — The life cycle of S. papillosus. (A) The life cycle of S

From: Soil temperature modifies effects of soil biota on plant growth

Figure 1. Blue light inactivation of Acinetobacter baumannii and keratinocytes in vitro. Bars denote SDs. From: Antimicrobial Blue Light Therapy for Multidrug-Resistant.

Figure 1. Conceptual framework.

Figure 6 Case 6: (A) MRA showed occlusion of the left internal carotid artery. (B) MRI 4 days before cell injection and (C) 7 days after cell injection.

Figure 1. Standardized coefficients for the SEM group model for heterosexual males. Latent constructs are shown in ellipses, and observed variables are.

Figure 1. Logos appearing in the choice experiment

Figure 1. Selection of papers.

Figure 1. Least square means of the swimming speed procedures, over a 6-month time period (24–30 months). Longevity was significantly predicted by higher.

Figure 1. Conceptual model of well-being related to involvement in theatre. From: Theatre Involvement and Well-Being, Age Differences, and Lessons From.

Fig. 1 Flow of ascertainment of cases with incident childhood IgA vasculitis reported by four sources From: Incidence of IgA vasculitis in children estimated.

Figure 1. System model. From: Ultra Dense Cells Management and Resource Allocation in Green Software-Defined Wireless Networks Comput J. 2017;60(10):

Figure 1 Flow chart showing the selection of publications identified in the literature search. From: GnRH antagonist versus long agonist protocols in IVF:

From: Where do we go from here

Figure 1. Overall survival of patients receiving alternative medicine (solid lines) vs conventional cancer treatment (dashed lines). Overall survival of.

Example 14. Schubert, Quartet in G Major, D

Fig. 2 Expression and subcellular localization of MSL8–GFP expressed from endogenous sequences. (A) Quantitative RT–PCR amplification of MSL8 transcripts.

Fig. 1 Selection of patients

Figure 1. Academic productivity and high academic income: top earners vs. the rest of academics. The average number of ‘peer-reviewed article equivalents’

Figure 1 Flow chart of search and selection strategy for studies in a systematic review of endometrial thickness during IUI with ovarian stimulation. *

Figure 1. Frailty components in mice vs humans.

Figure 1: Changing American Attitudes toward Marijuana and Same-Sex Marriage. Mean support for marijuana and same-sex marriage legalization. N=4,079. Source:

Figure 3. Hypothalamic–Pituitary–Adrenal (HPA)-axis functioning moderates crime exposure: regions of significance on X (crime). The lines represent two.

Figure 1. Time of initiation of therapeutic hypothermia according to who initiated it. Note the logarithmic scaling of the vertical axis. From: Initiation.

Figure 1: Time points at which sperm samples were analysed for aneuploidy frequencies in controls and cancer patients From: Sperm aneuploidy frequencies.

Fig. 2. DoFE for WGD retained genes of two subgenomes.

FIG. 1. Various models of rate variation across sites and lineages

Figure 1. Percentage of trainees is represented on the y-axis for each competency/knowledge item represented in the x-axis. Only Poor/Fair (P/F) ratings.

Figure 2 Comparison of pregnancy outcomes between true NC-FET and modified NC-FET. Odds ratio (OR) adjusted for clinical pregnancy (OR 0.90, 95% CI 0.73–1.12)

Figure 1 PRISMA flow diagram illustrating the process of selection of studies for inclusion in the systematic review. From: How effective are weight-loss.

Figure 1 Map of the Mediterranean Sea showing the location of Lampedusa island and the main area in which the study was carried out. From: Anthropogenic.

Figure 1. Impact ratings for prospective memory lapses for younger (~age 30), middle-age (~age 50), and older (~age 65) adults. From: Daily Memory Lapses.

Figure 1. Influence of endogenous and exogenous factors on aging

Figure 1. Scattergram of serum CA-125 levels in 775 consecutive patients who had been diagnosed with gynecologic disease by laparotomy or laparoscopy.

Figure 6. RRs for clinical cure rates stratified by different diseases

Fig. 5. A GC content and het/nonref-hom ratio relationship for exome regions. B GC content and het/nonref-hom ratio relationship for intron regions. C.

Figure 1. Percentage of participants in each group (holocaust survivors, prewar immigrants, and postwar immigrants) by the main coded strategies. From:

Figure 7 miRNA and mRNA gene expression changes in the Poor Group

Figure 1. The cell-lineage specification of the early mouse embryo

Figure 1. Patterns of HER2–PET/CT confronted with FDG–PET/CT, Maximum intensity projection. Lesion uptake was considered pertinent when visually higher.

Polymorphisms in gonadotropin and gonadotropin receptor genes as markers of ovarian reserve and response in in vitro fertilization Antonio La Marca,

Figure 1 Weighted social networks for (a) chase behavior and (b) display behavior. Each node represents an individual, and individuals are in the same.

Expression of cell cycle regulatory genes during primordial-primary follicle transition in the mouse ovary Chang-Eun Park, M.S., Kwang-Yul Cha, M.D.,

Nova2 Interacts with a Cis-Acting Polymorphism to Influence the Proportions of Drug- Responsive Splice Variants of SCN1A Erin L. Heinzen, Woohyun Yoon,

Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray.

Figure 4 ROMs have a morph-specific effect relative to active aggression but not display behavior in dominant males. ... Figure 4 ROMs have a morph-specific.

Figure 1 Flow diagram detailing the systematic review process.

Figure 1. Linkage analyses of the SNPs in the MRE11 gene and haplotype blocks. Haplotype blocks were defined for all ... Figure 1. Linkage analyses of.

Figure 1 Maternal relatedness between calves and non-calf unit members correlates with babysitting rate. Relatedness ... Figure 1 Maternal relatedness.

Figure 1 Relationships between pair indices of dance performance (joint entropy or mutual information) and the past ... Figure 1 Relationships between.

Fig. 1. —GO categories enriched in gene families showing high or low omega (dN/dS) values for Pneumocystis jirovecii. ... Fig. 1. —GO categories enriched.

Figure 1: Yearly net investment flows from Japan

Figure 1: Trade shares of South Korea's major trading partners (% of South Korea's total trade in goods) Figure 1: Trade shares of South Korea's major.

Presentation transcript:

Figure 1. Representative example of the pattern of oxygen consumption for assessment of mitochondrial function. The dashed line represents values from a cow of the AA genotype, and the blue line the values for a cow of the GG genotype. Excess electron transport system capacity was calculated as the ratio of maximum respiration and routine respiration. A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Figure 2. Models of the three-dimensional structure of COQ9 Figure 2. Models of the three-dimensional structure of COQ9. (A) Variant G, corresponding to the major allele; (B) variant A corresponding to the minor allele; (C) superimposed models of both isoforms of the protein. The residue affected by the SNP is shown in red in panel A and in green in panels B and C. A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Figure 3. Phylogeny of the mutation in COQ9 Figure 3. Phylogeny of the mutation in COQ9. The reference allele is indicated in red. All species distal to the common ancestor had the same reference allele unless indicated by placement of a distinct letter. For B. taurus, both alleles are presented (major/minor). The allele underlined is the one associated with superior fertility. A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Figure 4. Association of COQ9 genotype with body weight changes after calving during the first and second lactation of Holstein cows. Values are least-squares means ± SEM of daily body weights averaged for each week. The number of cows for each genotype was 86 AA, 223 AG, and 106 GG. Body weight was affected by the interaction between genotype and week after calving (P < 0.001) for both lactations. A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Figure 5. Expression of COQ9 in the endometrium, oocyte, and preimplantation embryo. All values are least-squares means ± SEM of the fold change of expression relative to the geometric mean of three housekeeping genes. (A) Changes in COQ9 expression in the endometrium during the first 7 days of the estrous cycle. Expression of COQ9 was measured for samples from 3 to 4 cows per day. There was no significant effect of day of the estrous cycle (P = 0.412). (B) COQ9 expression in the matured oocyte and early embryo. A total of four pools of 30 oocytes or embryos per pool were assessed for each stage. COQ9 expression was higher for oocytes and two-cell embryos than for embryos at other stages (P < 0.001). A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Figure 6. Expression of COQ9 in genotype-identified cumulus cells (A) and oocytes (B). Values are least-squares means ± SEM. The number of pools of oocytes or cumulus cells evaluated was 11 for AA, 20 for AG, and 12 for GG. Expression in cumulus cells was not affected by genotype (P = 0.1370), but expression in oocytes was affected by genotype (P < 0.001), with oocytes of the AG genotype having greater expression than either homozygote. A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Figure 7. Association of COQ9 genotype with markers of oocyte quality Figure 7. Association of COQ9 genotype with markers of oocyte quality. (A) Expression of BMP15 and GDF9 in oocytes of the three genotypes for COQ9. Values are least-squares means ± SEM. There were 11 pools of oocytes for AA, 20 for AG, and 12 for GG. There was no effect of genotype on expression of BMP15 (P = 0.779) or GDF9 (P = 0.685). (B) Mitochondrial copy number in oocytes of the three genotypes for COQ9. Values are least-squares means ± SEM. There were 11 pools of oocytes for 11 AA, 20 for AG, and 12 for GG. There was an additive effect of genotype on mitochondrial copy number in favor of the A allele (P < 0.0001) and a dominance effect (P < 0.0001). A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows† Biol Reprod. 2017;96(3):652-663. doi:10.1093/biolre/iox004 Biol Reprod | © The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com