Assist. Prof. Dr. Açelya Yılmazer Aktuna

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Presentation transcript:

Assist. Prof. Dr. Açelya Yılmazer Aktuna Cell Biology BME140 Lecture 7 DNA Replication Assist. Prof. Dr. Açelya Yılmazer Aktuna

DNA Replication DNA Replication Occurs at Sites Called Replication Factories DNA Replication Is Semi-discontinuous Steps: Initiation Elongation Termination

DNA Replication Replication fork DNA is always synthesized in the 5' to 3' direction Leading strand Lagging strant At the replication fork, many replication enzymes assemble on the DNA

DNA Replication DNA Helicase Replication Fork DNA Polymerase DNA clamp Single-Strand Binding (SSB) Proteins Topoisomerase DNA Gyrase DNA Ligase Okazaki Fragments Primase Telomerase