cell cycle 김다은 성균관대학교 / 약학과 2017.03.02

Contents Cell Cycle Introduction Interphase M Phase Cell Cycle check-point Cell Cycle regulator

Cell cycle Cell division / DNA duplication <Mother cell> <Daughter cells>

Interphase : Preparation Cell cycle Interphase : Preparation Cell cycle Interphase는 전체 세포주기의 90%이상을 차지 Mitotic phase (M-Phase) : Division

Cell cycle_Interphase G1 M - S Cell growth Cell growth checkpoint S G1 – G2 DNA replication DNA synthesis checkpoint G2 S - Cell grow more G1: M기 종료~DNA synthesis 시작 까지를 가리킴

Cell cycle_M Phase Prophase Metaphase Anaphase Prometaphase Telophase &Cytokinesis Prometaphase

Cell cycle checkpoint G1 checkpoint G2 Checks for spindle M Cell division or not Checks for Cell size, nutrients, DNA damage G1 checkpoint Checks for DNA damage, DNA replication completeness DNA repair or apoptosis G2 Checks for spindle M

Cell cycle regulator Prometaphase G1 – Rb protein phospholylation G1 / S – induce of initiation of DNA replication S – DNA replication M – Spindle formation Prometaphase

Tumor suppressor DNA damage DNA repair p53 Prometaphase apoptosis Cyclin D / Cdk4&6 E2F + Rb E2F Cyclin E (S phase) Rb p p21