Risk of gastrointestinal bleeding with direct oral anticoagulants: a systematic review and network meta-analysis Nick Burr, MBBS, Katie Lummis, MBChB,

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Risk of gastrointestinal bleeding with direct oral anticoagulants: a systematic review and network meta-analysis Nick Burr, MBBS, Katie Lummis, MBChB, Ruchit Sood, MBChB, John Samuel Kane, MBChB, Aaron Corp, MBChB, Dr Venkataraman Subramanian, MD The Lancet Gastroenterology & Hepatology Volume 2, Issue 2, Pages 85-93 (February 2017) DOI: 10.1016/S2468-1253(16)30162-5 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Study selection ISTH=International Society on Thrombosis and Haemostasis. ICD-9=International Classification of Diseases, 9th revision. The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: (10.1016/S2468-1253(16)30162-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Network plot Each treatment is represented by a circle. The size of the circle is proportional to the number of patients on this drug. The thickness of the connecting line represents the number of studies comparing the two drugs. The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: (10.1016/S2468-1253(16)30162-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Forest plot of the risk of (A) major gastrointestinal bleeding and (B) all gastrointestinal bleeding with different anticoagulants Bayesian network meta-analysis. Vague and informative prior results are shown. IRR=incidence rate ratio. CrI=credible interval. The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: (10.1016/S2468-1253(16)30162-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 4 League table ranking anticoagulants in the order of risk of (A) major gastrointestinal bleeding and (B) all gastrointestinal bleeding Results shown as incidence rate ratios (IRRs) with 95% credible intervals. (A) Major gastrointestinal bleeding as defined by International Society on Thrombosis and Haemostasis or International Classification of Diseases, 9th revision, criteria. Results do not reach statistical significance. (B) All gastrointestinal bleeding is defined as the total number of bleeding events for which severity was not defined in the study. The Lancet Gastroenterology & Hepatology 2017 2, 85-93DOI: (10.1016/S2468-1253(16)30162-5) Copyright © 2017 Elsevier Ltd Terms and Conditions