Professor Brian S. Yandell

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Presentation transcript:

Professor Brian S. Yandell joint faculty appointment across colleges: 50% Horticulture (CALS) 50% Statistics (Letters & Sciences) Biometry Program MS degree program across campus Consulting Facility across CALS & VETMED teaching & research statistical methods in biological sciences

Biometry Program MS Degree Consulting Facility co-advise with biologist bridge biology & stats project & oral report consulting experience 10 completed, 1 current Genetics Botany, Dairy Sci (2), Hort, Land Resources, Meat & Animal Sci, Wildlife Ecology (2), Zoology Consulting Facility statistical consulting 5 faculty, 2-3 students computing assistance 2 staff + operators self-help model guide research ideas build skill sets collaboration students faculty staff CALS & VETMED & L+S

Research & Teaching statistical genetics statistical ecology QTLs in Brassica time to flowering QTLs in mouse model diabetes model multiple generations micro-arrays 2 current students statistical ecology population ethology individual-based simulations stats consulting communication skills write, plot, talk bridge stats & biology linear models experimental design complicated analysis problems directly from consulting published textbook

The intercross (from K Broman) 

Brassica Flowering Time vernalization effect (4/8 week) on days to flower genetic cross of Brassica parents Stellar (annual canola) Major (biennial rapeseed) 105 double haploid (DH) lines homozygous at every locus

Brassica Credible Regions

glucose insulin (courtesy AD Attie)

studying diabetes in an F2 mouse model: segregating panel from inbred lines B6.ob x BTBR.ob  F1  F2 selected mice with ob/ob alleles at leptin gene (Chr 6) sacrificed at 14 weeks, tissues preserved physiological study (Stoehr et al. 2000 Diabetes) mapped body weight, insulin, glucose at various ages gene expression studies RT-PCR for a few mRNA on 108 F2 mice liver tissues (Lan et al. 2003 Diabetes; Lan et al. 2003 Genetics) Affymetrix microarrays on 60 F2 mice liver tissues U47 A & B chips, RMA normalization design: selective phenotyping (Jin et al. 2004 Genetics)

2M observations 30,000 traits 60 mice