Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban.

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Presentation transcript:

Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study) Robert A. Wood, MD, Gordon R. Bloomberg, MD, Meyer Kattan, MD, Kathleen Conroy, MD, Megan T. Sandel, MD, MPH, Amy Dresen, BS, Peter J. Gergen, MD, MPH, Diane R. Gold, MD, MPH, John C. Schwarz, MS, Cynthia M. Visness, PhD, MPH, James E. Gern, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 4, Pages 913-919.e6 (April 2011) DOI: 10.1016/j.jaci.2010.12.1122 Copyright © 2011 Terms and Conditions

Fig 1 Relationships among the major atopic outcomes, including those who have IgE data and EASI scores recorded at 3 or 12 months (n = 332). Those who have no atopic outcomes (n = 87 [26%]) are included in the calculation of the percentages but are not displayed in the Venn diagram. Significant associations were detected between eczema and sensitization (P = .005). No associations were found between eczema and any, single, or multiple episodes of wheeze or between positive IgE and any, single, or multiple episodes of wheeze. Journal of Allergy and Clinical Immunology 2011 127, 913-919.e6DOI: (10.1016/j.jaci.2010.12.1122) Copyright © 2011 Terms and Conditions

Fig 2 Relationships between atopic outcomes and environmental exposures. Boldfaced lines and solid circles represent statistical significance in models adjusted for site, season of birth, and child’s sex. EPDS, Edinburgh Postnatal Depression Scale (mean of first-year measurements; odds ratio for 5-level increase); PSS, Perceived Stress Score. Odds ratios for cotinine and allergens are given for a 1-log increase. Journal of Allergy and Clinical Immunology 2011 127, 913-919.e6DOI: (10.1016/j.jaci.2010.12.1122) Copyright © 2011 Terms and Conditions

Fig 3 Relationships between atopic outcomes and cord blood cytokine profiles. Boldfaced lines and solid circles represent statistical significance in models adjusted for site, season of birth, and child’s sex. Cytokine factors are scaled to 5 levels, where 0 represents nondetectable levels and 1 to 4 represent quartiles of detectable levels. Odds ratios are given for a 1-step increase. Journal of Allergy and Clinical Immunology 2011 127, 913-919.e6DOI: (10.1016/j.jaci.2010.12.1122) Copyright © 2011 Terms and Conditions