IL-6 significantly correlates with p-STAT3 expression and presents high variceal bleeding with mortality in cirrhotic patients: A cross-sectional study

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IL-6 significantly correlates with p-STAT3 expression and presents high variceal bleeding with mortality in cirrhotic patients: A cross-sectional study Jung-Ta Kao, Cheng-Ju Yu, Chun-Lung Feng, Shu-Mei Tsai, Yao-Li Chen, Yi-Ying Wu Journal of Microbiology, Immunology and Infection Volume 50, Issue 3, Pages 286-296 (June 2017) DOI: 10.1016/j.jmii.2015.03.001 Copyright © 2015 Terms and Conditions

Figure 1 The expression of IL-6, IL-27, TNF-α, and VEGF in separate subgroups. * A value of p < 0.05 was defined as statistically significant. Journal of Microbiology, Immunology and Infection 2017 50, 286-296DOI: (10.1016/j.jmii.2015.03.001) Copyright © 2015 Terms and Conditions

Figure 2 IL-6 expression presented significant correlation with deteriorating liver condition in cirrhotic patients. * A value of p < 0.05 was defined as statistically significant. Journal of Microbiology, Immunology and Infection 2017 50, 286-296DOI: (10.1016/j.jmii.2015.03.001) Copyright © 2015 Terms and Conditions

Figure 3 IL-6 expression presented significant correlation with varices formation (A) and variceal bleeding (B) in cirrhotic patients. * A value of p < 0.05 was defined as statistically significant. Journal of Microbiology, Immunology and Infection 2017 50, 286-296DOI: (10.1016/j.jmii.2015.03.001) Copyright © 2015 Terms and Conditions

Figure 4 IL-6 presented the strongest correlation with 3-month (A) and 6-month mortality (B) in cirrhotic patients. * A value of p < 0.05 was defined as statistically significant. Journal of Microbiology, Immunology and Infection 2017 50, 286-296DOI: (10.1016/j.jmii.2015.03.001) Copyright © 2015 Terms and Conditions

Figure 5 Immunohistochemical studies of p-STAT1 and p-STAT3 in three identical cirrhotic tissues. Immunoreactivity exhibited in nuclei or cytoplasm of hepatocyte was designated Level I (<10%), II (≧10% to <25%), or III (≧25%) [×400 magnification; the brown cell (arrow) shows positive immunostain] (A). Tissue p-STAT3 presented a positive correlation between increasing immunoreactivities levels with IL-6 expressions as compared with p-STAT1 with IL-6 in CH with LC patients (r = 0.316, p = 0.022; r = −0.137, p = 0.334, respectively) and in LC patients (r = 0.737, p = 0.010; r = −0.400, p = 0.223, respectively) (B,C). * A value of p < 0.05 was defined as statistically significant. Journal of Microbiology, Immunology and Infection 2017 50, 286-296DOI: (10.1016/j.jmii.2015.03.001) Copyright © 2015 Terms and Conditions