Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas Alexandre M Ab' Saber, MD, Ledo Mazzei Massoni Neto,

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Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas Alexandre M Ab' Saber, MD, Ledo Mazzei Massoni Neto, Cristina P Bianchi, Bruno B Ctenas, MD, Edwin R Parra, MD, Esmeralda M Eher, João Carlos Pereira, MD, Teresa Takagaki, MD, PhD, Nise H Yamaguchi, MD, PhD, Vera L Capelozzi, MD, PhD The Annals of Thoracic Surgery Volume 77, Issue 6, Pages 1883-1890 (June 2004) DOI: 10.1016/j.athoracsur.2003.11.047

Fig 1 (A) LCC with nucleoli evident, lower nuclear-to-cytoplasmic ratio, and absence of neuroendocrine features. (Hematoxylin & eosin; ×200 before reduction.) (B) LCNEC (hematoxylin & eosin; ×100 before reduction) and (C) LCCNM (hematoxylin & eosin; ×200 before reduction) show a neuroendocrine morphology with organoid nesting, palisading, and rosettes. Numerous mitoses are seen. Cytologic features include large cell size, fine chromatin, and nucleoli evident. (D) The tumor cells stained with anti-chromogranin A antibody; only the LCNEC tumors stained for chromogranin. (×200 before reduction.) (LCC = large cell carcinoma; LCNEC = large cell neuroendocrine carcinoma; LCCNM = large cell carcinoma with neuroendocrine morphology.) The Annals of Thoracic Surgery 2004 77, 1883-1890DOI: (10.1016/j.athoracsur.2003.11.047)

Fig 2 (A) Kaplan–Meier curve demonstrating the impact of surgery on survival. Surgery type: - ♢ - = pneumonectomy; — ■ — = bilobectomy; –▵– = lobectomy. (B) Effect of histologic subtype on survival. Group: — ■ — = LCNM; - ♢ - = LCNEC; –▵– = LCC. (LCC = large cell carcinoma; LCNM = large cell carcinoma with neuroendocrine morphology; LCNEC = large cell neuroendocrine carcinoma.) (C) Kaplan–Meier curve demonstrating the effect of MVD on survival. Upper curve < 30% of MVD in tumor; lower curve < 30% of MVD in tumor. Cut points in MVD: - - - = 3.01–12.8%; —— = 0.0–3.0%. (MVD = microvessel density.) (D) Kaplan–Meier curve demonstrating the effect of p21 on survival. Upper curve < 35% of tumor staining; lower curve < 37% of tumor staining. Cut points in p21: - - - = 3.7–46.6%; —— = 0.0–3.7%. The Annals of Thoracic Surgery 2004 77, 1883-1890DOI: (10.1016/j.athoracsur.2003.11.047)