Advancing Care Forward in Squamous Cell Carcinoma of the Head and Neck

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Presentation transcript:

Advancing Care Forward in Squamous Cell Carcinoma of the Head and Neck

This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

Epidemiology of SCCHN

Tumor-Infiltrating Lymphocytes Are Present in Some HNCs

Tumor Immunity Cycle Goal: Activated T Cells Kill Tumor Cells

Modulation of the Immune System Through Checkpoint Inhibitor Pathways

Challenges in SCCHN Treatment

Case Study 1: 65-Year-Old With Stage IVB, HPV-Positive, Oropharynx Cancer

Nivolumab: CheckMate 141 Efficacy Data

Nivolumab: Data Related to Prior Treatments

Nivolumab: CheckMate 141 Biomarker Data

Pembrolizumab: Trials in R/M SCCHN

Durvalumab: Study 1108

Case Study 2: 69-Year-Old Patient With Stage IVB, HPV-Negative Larynx Cancer

Pseudoprogression

Ongoing Studies

Pembrolizumab Plus Epacadostat: Preliminary Data

Immune-Related AEs

Hypothyroidism

Pneumonitis

Take Home Messages

Abbreviations

Abbreviations (cont)