Advancing Care Forward in Squamous Cell Carcinoma of the Head and Neck
This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.
Epidemiology of SCCHN
Tumor-Infiltrating Lymphocytes Are Present in Some HNCs
Tumor Immunity Cycle Goal: Activated T Cells Kill Tumor Cells
Modulation of the Immune System Through Checkpoint Inhibitor Pathways
Challenges in SCCHN Treatment
Case Study 1: 65-Year-Old With Stage IVB, HPV-Positive, Oropharynx Cancer
Nivolumab: CheckMate 141 Efficacy Data
Nivolumab: Data Related to Prior Treatments
Nivolumab: CheckMate 141 Biomarker Data
Pembrolizumab: Trials in R/M SCCHN
Durvalumab: Study 1108
Case Study 2: 69-Year-Old Patient With Stage IVB, HPV-Negative Larynx Cancer
Pseudoprogression
Ongoing Studies
Pembrolizumab Plus Epacadostat: Preliminary Data
Immune-Related AEs
Hypothyroidism
Pneumonitis
Take Home Messages
Abbreviations
Abbreviations (cont)