Volume 30, Issue 1, Pages (February 2014)

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Presentation transcript:

Volume 30, Issue 1, Pages 58-64 (February 2014) Efficacy and safety of novel anticoagulant dabigatran in clinical practice for Japanese patients with non-valvular atrial fibrillation Koji Miyamoto, Takeshi Aiba, Ikutaro Nakajima, Yuko Yamada, Hideo Okamura, Takashi Noda, Kazuhiro Satomi, Masaharu Ishihara, Toshihisa Anzai, Satoshi Yasuda, Hisao Ogawa, Shiro Kamakura, Wataru Shimizu Journal of Arrhythmia Volume 30, Issue 1, Pages 58-64 (February 2014) DOI: 10.1016/j.joa.2013.04.010 Copyright © 2013 Japanese Heart Rhythm Society Terms and Conditions

Fig. 1 (a) Relationship between age and number of patients who received dabigatran (red=300mg/day, blue=220mg/day). Fig. 1 and (b) Relationship between eCCr and number of patients who received dabigatran (red=300mg/day, blue=220mg/day). eCCr=estimated creatinine clearance. Journal of Arrhythmia 2014 30, 58-64DOI: (10.1016/j.joa.2013.04.010) Copyright © 2013 Japanese Heart Rhythm Society Terms and Conditions

Fig. 2 Relationship between age and eCCr. The eCCr was inversely correlated to age (p<0.0001). eCCr=Estimated creatinine clearance. Journal of Arrhythmia 2014 30, 58-64DOI: (10.1016/j.joa.2013.04.010) Copyright © 2013 Japanese Heart Rhythm Society Terms and Conditions

Fig. 3 Relationship between APTT values and eCCr. The APTT was inversely correlated to the eCCr. APTT=Activated partial thromboplastin time, eCCr=estimated creatinine clearance. Journal of Arrhythmia 2014 30, 58-64DOI: (10.1016/j.joa.2013.04.010) Copyright © 2013 Japanese Heart Rhythm Society Terms and Conditions

Fig. 4 Relationship between APTT values and sampling time (time of day). The APTT was not dependent on the time of day for each dabigatran dose (blue=220mg/day, red=300mg/day). APTT=Activated partial thromboplastin time. Journal of Arrhythmia 2014 30, 58-64DOI: (10.1016/j.joa.2013.04.010) Copyright © 2013 Japanese Heart Rhythm Society Terms and Conditions

Fig. S1 Relationship between APTT values from the first and second occasions it was measured for each patient. The day-to-day difference of the APTT values for each patient was not substantial, indicating that the APTT value was highly reproducible. APTT=Activated partial thromboplastin time. Journal of Arrhythmia 2014 30, 58-64DOI: (10.1016/j.joa.2013.04.010) Copyright © 2013 Japanese Heart Rhythm Society Terms and Conditions