Hyaluronic acid skin fillers: Adverse reactions and skin testing

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Presentation transcript:

Hyaluronic acid skin fillers: Adverse reactions and skin testing Nicholas J. Lowe, MD, FRCPa,b,c, C.Anne Maxwell, MB, ChBa, Philippa Lowe, MB, ChBa, Michael G. Duickb, Kishor Shah, MDa,d Journal of the American Academy of Dermatology Volume 45, Issue 6, Pages 930-933 (December 2001) DOI: 10.1067/mjd.2001.117381 Copyright © 2001 American Academy of Dermatology, Inc Terms and Conditions

Fig. 1 Skin-tested forearm 8 weeks after intradermal injection of HA filler (Hylaform) with severe grade III inflammatory reaction. Journal of the American Academy of Dermatology 2001 45, 930-933DOI: (10.1067/mjd.2001.117381) Copyright © 2001 American Academy of Dermatology, Inc Terms and Conditions

Fig. 2 Example of delayed inflammatory reaction to HA filler (Hylaform) occurring 8 weeks after implantation. Journal of the American Academy of Dermatology 2001 45, 930-933DOI: (10.1067/mjd.2001.117381) Copyright © 2001 American Academy of Dermatology, Inc Terms and Conditions

Fig. 3 Another patient showing inflammatory skin reactions 7 weeks after implantation (Hylaform). Journal of the American Academy of Dermatology 2001 45, 930-933DOI: (10.1067/mjd.2001.117381) Copyright © 2001 American Academy of Dermatology, Inc Terms and Conditions

Fig. 4 A and B, Histologic features of biopsy specimen taken from skin affected by inflammatory reaction (see text for description of features). A deep, predominantly lymphocytic and plasma cell infiltrate is seen (Hylaform). Journal of the American Academy of Dermatology 2001 45, 930-933DOI: (10.1067/mjd.2001.117381) Copyright © 2001 American Academy of Dermatology, Inc Terms and Conditions