Hyaluronic acid stimulates tumor-cell proliferation at wound sites

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Presentation transcript:

Hyaluronic acid stimulates tumor-cell proliferation at wound sites Yoko Matsui, MD, Masafumi Inomata, MD, Koichi Izumi, MD, Kazuya Sonoda, MD, Norio Shiraishi, MD, Seigo Kitano, MD, FACS Gastrointestinal Endoscopy Volume 60, Issue 4, Pages 539-543 (October 2004) DOI: 10.1016/S0016-5107(04)01890-5 Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 A, Increases in tumor volume over time. B, Tumor weight on day 14 after tumor-cell inoculation. Gastrointestinal Endoscopy 2004 60, 539-543DOI: (10.1016/S0016-5107(04)01890-5) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 A, Increases in tumor volume over time. B, Tumor weight on day 14 after tumor-cell inoculation. Gastrointestinal Endoscopy 2004 60, 539-543DOI: (10.1016/S0016-5107(04)01890-5) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 2 PCNA-labeling index of tumors in HA and control groups on day 14 after inoculation of tumor cells. Gastrointestinal Endoscopy 2004 60, 539-543DOI: (10.1016/S0016-5107(04)01890-5) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 3 A, Photomicrograph showing expression of CD44 protein in section of tumor tissue from wound site in HA group mouse (IM7 antibody stain; bar=60 μm). B, Photomicrograph showing nonexpression of CD44 protein in section of tumor tissue from wound site in control group mouse (IM7 antibody stain; bar=60 μm). Gastrointestinal Endoscopy 2004 60, 539-543DOI: (10.1016/S0016-5107(04)01890-5) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 3 A, Photomicrograph showing expression of CD44 protein in section of tumor tissue from wound site in HA group mouse (IM7 antibody stain; bar=60 μm). B, Photomicrograph showing nonexpression of CD44 protein in section of tumor tissue from wound site in control group mouse (IM7 antibody stain; bar=60 μm). Gastrointestinal Endoscopy 2004 60, 539-543DOI: (10.1016/S0016-5107(04)01890-5) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 4 A, Immunoblot analysis with specific rat anti-mouse CD44 monoclonal antibody (mAb; clone KM114), showing CD44 expression levels in tumors. B, Two lines on right show CBB stain of each group. Gastrointestinal Endoscopy 2004 60, 539-543DOI: (10.1016/S0016-5107(04)01890-5) Copyright © 2004 American Society for Gastrointestinal Endoscopy Terms and Conditions