Supplemental Figure 1 A B C D E F

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Supplemental Figure 1 A No. at risk T T T

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Supplemental Figure 1 A B C D E F 250 500 750 1 2 3 4 5 6 LDL Cholesterol serum PCSK9 (ng/ml) A Total Cholesterol 250 500 750 1 2 3 4 5 6 7 8 9 serum PCSK9 (ng/ml) B r= 0.3312 p< 0.0001 r= 0.3919 p< 0.0001 250 500 750 1 2 3 HDL Cholesterol serum PCSK9 (ng/ml) C Triglycerides 250 500 750 0.5 1 1.5 2 2.5 3 3.5 4 serum PCSK9 (ng/ml) D r= 0.2647 p= 0.0001 r= 0.0749 p= 0.2848 Age (years) 250 500 750 10 20 30 40 50 60 70 80 90 serum PCSK9 (ng/ml) E 250 500 750 5 10 15 20 25 30 35 40 45 50 BMI (kg/m2) serum PCSK9 (ng/ml) F r= 0.0510 p= 0.4655 r= 0.0185 p= 0.7941 Supplemental Figure 1: The relationship between serum PCSK9 and lipoprotein parameters, age and body mass index (BMI) by Spearmen correlation (r) and significance (p) using GraphPad Prism 5 Software.