100 200 300 400 500 600 700 No muscle wasting Muscle wasting 6-minute walk (m) P=0.003 Figure 1a 500 750 1000 1250 1500 1750 2000 2250 2500 2750 3000 No muscle wasting Muscle wasting Absolute peak VO2 (ml/min) P < 0.05 Figure 1b

15 20 25 30 35 40 45 50 55 60 C E/e'≥15 B E/e' 9-14 A E/e'≤8 PANOVA=0.0003 Right handgrip strength (kg) Figure 2a 20 30 40 50 60 70 80 Right quadriceps strength (kg) C E/e'≥15 B E/e' 9-14 A E/e'≤8 PANOVA=0.002 Figure 2b

5 10 15 20 25 30 35 40 Appendicular lean mass (kg)/BMI E/e' P=0.02 R=-2.2   Figure 3

Absolute peak VO2 (ml/min) 500 750 1000 1250 1500 1750 2000 2250 2500 2750 3000 15 20 25 30 35 40 Appendicular lean mass (kg) P < 0.0001 R=0.67 Figure 4

20 30 40 50 60 70 80 90 100 2 3 4 5 6 7 Vas-Score P=0.0005 R=0.50 Figure 5a Vas-Score 20 30 40 50 60 70 80 90 100 2 3 4 5 6 7 P= 0.01 R=0.38 Figure 5b Muscle strength/muscle mass in the left leg (both in kg) Muscle strength/muscle mass in the right (both in kg)