Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort.

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Presentation transcript:

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study Kanetee Busiah, MD, Séverine Drunat, PharmD, Prof Laurence Vaivre-Douret, PhD, Amélie Bonnefond, PhD, Albane Simon, MD, Isabelle Flechtner, MD, Bénédicte Gérard, PharmD, Nathalie Pouvreau, MSc, Caroline Elie, MD, Revital Nimri, MD, Liat De Vries, MD, Nadia Tubiana-Rufi, MD, Chantal Metz, MD, Anne-Marie Bertrand, MD, Sylvie Nivot-Adamiak, MD, Marc de Kerdanet, MD, Chantal Stuckens, MD, Farida Jennane, MD, Pierre-François Souchon, MD, Claire Le Tallec, MD, Christelle Désirée, MSc, Sabrina Pereira, MSc, Aurélie Dechaume, MSc, Prof Jean-Jacques Robert, MD, Prof Moshe Phillip, MD, Raphaël Scharfmann, PhD, Prof Paul Czernichow, MD, Prof Philippe Froguel, MD, Martine Vaxillaire, PharmD, Prof Michel Polak, MD, Prof Hélène Cavé, PharmD The Lancet Diabetes & Endocrinology Volume 1, Issue 3, Pages 199-207 (November 2013) DOI: 10.1016/S2213-8587(13)70059-7 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Participant selection and analyses The Lancet Diabetes & Endocrinology 2013 1, 199-207DOI: (10.1016/S2213-8587(13)70059-7) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier curve of diabetes remission in index patients with 6q24 abnormalities or KATP channel mutations Data only available for 106 index patients. Tick marks indicate last visit. The Lancet Diabetes & Endocrinology 2013 1, 199-207DOI: (10.1016/S2213-8587(13)70059-7) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 3 Kaplan-Meier curve of diabetes recurrence in index patients with 6q24 abnormalities or KATP channel mutations Data only available for 63 index patients. Tick marks indicate last visit. The Lancet Diabetes & Endocrinology 2013 1, 199-207DOI: (10.1016/S2213-8587(13)70059-7) Copyright © 2013 Elsevier Ltd Terms and Conditions