Acyl chlorides.

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Presentation transcript:

Acyl chlorides

Preparation of an acyl chloride The acyl group Carboxylic acid RCOOH Acyl group RCO Acyl chloride RCOCl Preparation of an acyl chloride From carboxylic acid and thionyl chloride, SOCl2 Ethanoic acid Thionyl chloride Ethanoyl chloride

Acyl chlorides in synthesis Acyl chlorides react with nucleophiles

Acyl chlorides  Carboxylic acids and Esters Carboxylic acids using water Water Esters using alcohols HCl hydrochloric acid Alcohol

Acyl chlorides  Amides Primary amides using ammonia Ammonia Secondary amides using primary amines Primary amine

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